A Novel Pathway for the Biosynthesis of Heme in <i>Archaea</i>: Genome-Based Bioinformatic Predictions and Experimental Evidence

<table>Proposal for the novel, alternative heme biosynthesis pathway in archaea. Archaeal heme biosynthesis starts with the SAM-dependent methylation of UROGEN to precorrin-2 by a SUMT and potentially proceeds <i>via</i> oxidation of precorrin-2 to sirohydrochlorin by PC2-DH. The side chain modifications (highlighted by dashed circles) including acetate group decarboxylation on rings C and D, acetate group removal on rings A and B, and vinyl group formation on rings A and B are potentially catalyzed by the Ahb-Nir proteins.</table>

Archaea

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Figure 3: A Novel Pathway for the Biosynthesis of Heme in <i>Archaea</i>: Genome-Based Bioinformatic Predictions and Experimental Evidence 

Archaea

A Novel Pathway for the Biosynthesis of Heme in Archaea: Genome-Based Bioinformatic Predictions and Experimental Evidence

Figure 3