Review Article

Archaea Signal Recognition Particle Shows the Way

Table 1

High-resolution structures of archaeal SRP components. Indicated are the archaea subdomains (Crenarchaeota or Euryarchaeota), species names, components, and methods (X-Ray diffraction of NMR) used for structure determination. The pdb IDs allow easy retrieval of the coordinates [18]. The protein-conducting channel is abbreviated as PCC. Additional nonarchaea SRP high-resolution structures are listed at http://rnp.uthct.edu/rnp/SRPDB/srpstructures.html.

SubdomainsSpeciesComponentsMethodspdbReferences

CrenarchaeotaAcidianus ambivalensSRP54NGX-Ray1J8M,1J8Y[19]
Sulfolobus solfactaricusSRP54 with helix 8X-Ray1QZW[20]
SRP54 dimerX-Ray1QZX[20]
SRP54 with signal peptideX-Ray3KL4[21]
SRP19 with helix 6 and helix 8X-Ray3KTV,3KTW[22]
EuryarchaeotaArchaeoglobus fulgidusSRP19NMR1KVN,1KVV[23]
SRP54MNMR2JQE[24]
Methanococcus jannaschiiSRP19 with SRP54 with RNAX-Ray2V3C[25]
SRP19 with helix 6 and helix 8X-Ray1LNG[26]
Helix 6 and helix 8X-Ray1Z43[27]
PCCX-Ray1RHZ,1RH5[28]
Pyrococcus furiosusSRP19X-Ray3DLU,3DLV,3DM5[29]
SRP54X-Ray3DLU,3DLV,3DM5[29]
FtsYX-Ray3E70,3DM9,3DMD[30]