Review Article

Rings in the Extreme: PCNA Interactions and Adaptations in the Archaea

Figure 3

(a) Interaction of PfuPol with a monomeric mutant form of PfuPCNA (3A2F) [29]. The interacting proteins are shown coloured by spectrum from the N-terminus (blue) to the C-terminus (red). (b) Interactions of AfuRNase H with AfuPCNA (3P83). Three protein chains are bound in the structure, for clarity chain D has been removed. The PCNA ring is coloured purple, light, and dark blue. The chain occluding the central pore is coloured in salmon, and one of the two chains oriented away from the pore is coloured grey. The position of the key interacting residue is indicated [12].
951010.fig.003a
(a)
951010.fig.003b
(b)