Archaeal Nucleic Acid Ligases and Their Potential in Biotechnology

Table 2

Properties of archaeal RNA ligases.

Organism	UniProt ID	PDB ID	Co-Factor		Properties	Reference
Pyrococcus abyssi	Q9UYG2	2VUG	ATP	85–90°C	Efficient at forming adenylated RNA but not so efficient at strand joining. Forms circular products.	[62]
Methanothermobacter thermautotrophicus	O27289	—	ATP	65°C	Circularises single-stranded RNA and single-stranded DNA.	[63]

: temperature optimum for the RNA ligase in vitro.