Fundamental Characteristics of AAA+ Protein Family Structure and Function

Figure 2

Clade-specific features of the AAA+ domain. (a) The simplest AAA+ domain is characterized by an α-β-α topology with a C-terminal α-helical lid domain. Helices and strands within the base domain are shown as blue cylinders and yellow arrows, respectively, and lid domain helices are represented by green cylinders. (b–h) A crystal structure of a characteristic member of each clade is shown in cartoon representation with helices and strands colored as blue and yellow, respectively. The insertions that distinguish each clade are highlighted in salmon. Each structure contains a bound nucleotide molecule that is shown in stick. The protein topology cartoon in (a) was prepared using the TopDraw software package [42]. All structure representations in the figure were prepared with the Pymol software package [43] and PDB accession codes 2CHG [44] (b), 2V1U [45] (c), 4D81 [46] (d), 2GXA [40] (e), 1KSF [47] (f), 1NY5 [48] (g), and 4R7Y [41] (h).

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