Molecular Regulation of Striatal Development: A Review

Figure 6

Schematic coronal section through the developing telencephalon at E12.5—the dorsal and ventral subdomains are shown and defined by unique gene expression patterns. Dorsal telencephalic markers shown are Emx1/2, Ngn1/1, and Pax6. The ventral telencephalic markers shown can be split into identifying the LGE or MGE. Mash1(Ascl1), Gsx1/2, and Dlx1/2 are associated with the LGE (specifically the vLGE), and Nkx2.1 is associated with the MGE. Some of the gene interactions are shown on the diagram. One of the important interactions is between Pax6 and Gsx2; these genes work together to ensure the subpallalial/pallial border is maintained. Arrows denote positive interactions; T-bars denote inhibitory control. The green arrows represent the genetic signalling that has been unravelled in more recent data and occurs at later time points. Figure adapted from [42].