Review Article
Etiopathogenesis of Insulin Autoimmunity
Table 2
HLA haplotypes in the general population conferring significant risk for islet autoimmunity and type 1 diabetes.
| | HLA-DQ | References |
| | (a) Type 1 diabetes |
| | Europeans | | | A1*03:01-B1*03:02 | [54, 55] | | A1*05:01-B1*02:01 | [56] | | French native | | | DRB1*04:05-DQA1*03:03-B1*03:02 | [57] | | Mediterranean | | | DRB1*04:05-DQ A1*03-B1*02 | | | Black populations | | | DRB1*07-DQ A1*03-B1*02 | | | Japanese (haplotypes) | | | DRB1*04:05-DQA1*03:01/02?-DQB1*04:01 | [35–37] | | DRB1*09:01-DQA1*03:02-DQB1*03:03 | [35–37] | | DRB1*08:02-DQA1*03:01-DQB1*03:02 | [36, 37] | | DRB1*04:05-DQA1*03:01-DQB1*03:02 | [37] | | DRB1*03:01-DQA1*05:01-DQB1*02:01 | [37] | | DRB1*11:01-DQB1*03:01 | [36] | | DRB1*11:01-DQB1*03:02 | [36] | | DRB1*13:02-DQB1*06:04 | [36] | | Koreans (haplotypes) | | | DRB1*03:01-DQB1*02:01 | [58] | | DRB1*04:01-DQB1*03:02 | [58] | | DRB1*04:05-DQB1*03:02 | [58] | | DRB1*04:07-DQB1*03:02 | [58] | | DRB1*04:05-DQB1*04:01 | [35] | | DRB1*09:01-DQB1*03:03 | [35, 58] | | Chinese (haplotypes) | | | DRB1*09:01-DQA1*03:01/02-B1*03:03 | [38] | | DQA1*03-DQB1*03:03 | [39] | | DQA1*03-DQB1*04:01 | [39] | | DQA1*05-DQB1*02:01 | [39] | | Indians (haplotypes) | | | DRB1*03:01-DQA1*05:01-B1*02:01 | [59] | | DRB1*04:01/02/04/05-DQA1*03:01/02-B1*02:01 | [38] | | Sub-Saharan Africa (haplotypes) | | | DRB1*03:01-DQA*05:01 | [60] | | DRB1*04-DQA*03 | [60] | | DRB1*04-DQB*03:02 | [60] | | DRB1*03:01-DQB*02:01 | [60] | | DQA*05:01-DQB*02:01 | [60] | | DQA*03-DQB*03:02 | [60] | | Latin America (haplotypes) | | | DRB1*04:05-DQB1*03:02 | [61] | | DRB1*03:01-DQB1*05:01 | [61] | | DRB1*04:01-DQB1*03:02 | [61] | | DRB1*04-DQA1*03:01-DQB1*03:02 | [61] |
| | (b) Insulin autoimmune syndrome (haplotypes) |
| | DRB1*04:06-DQA1*03:01-B1*03:02 | [46, 47] |
|
|
