Etiopathogenesis of Insulin Autoimmunity

Table 3

Proinsulin and insulin peptides recognized by HLA-DQ, HLA-DR, and HLA-A2 compared to the epitopes recognized by IAA.

Binding molecule	Proinsulin/insulin sequence	Reference
HLA—Class II
DQ8 (B1*03:02)	B9–B23	[62]
DQ8c (A1*03:01-B1*03:02)	B13–B21	[63]
DQ2c (A1*05:01-B1*02:01)	B13–B21	[63]
DQ2t (A1*03:01-B1*02:01)	B13–B21	[63]
DQ8t (A1*05:01-B1*03:02)	B13–B21	[63]
DQ6.2 (A1*01:02-B1*06:02)	B6–B14	[63]
DRB1*04:01	A1–A15	[42]
DR 04:01	C19-A3, C35-A19	[64]
DR 04:03	C35-A19, A8–A21	[64]
DR4	A1–A13	[65]
DRB1*04-DQ8	B11-C24, C28-A21, B20-C4, C18-A1	[66]
DRB1*04-DQ8	B1–B16, B11–B27, C13–C29	[67]
HLA—Class I
A2	C6(5)–C14	[68]
	C6–C15
A2 (A*02:01)	B10–B18	[69]
A2-B8	B10–B18	[70]
A1-B8	B17–B26	[70]
A2	B5–B14	[71]
A3	C22–C30, C25–C34	[71]
B7	S4–S13	[71]
A2	S15–23	[52]
IAA
DRB1*04:06	B3 (asp)	[72, 73]
DRB1*04-DQB1*03:02	A8–A13	[74]
Unknown	Insulin, not proinsulin	[75]
Unknown	A8–A10	[76, 77]
Unknown	B1–B3, A17
Unknown	B1–B3, A8–A13	[78]

c is cis and t is trans in transcription. S is signal peptide.