Direct Vasocontractile Activities of Bupivacaine Enantiomers on the Isolated Rat Thoracic Aorta

Table 1

EC₅₀ values and maximum contraction by bupivacaines.

Bupivacaine	EC50(×10^−5)	Emax (g)
S (−)	7.3 ± 2.9	0.31 ± 0.06
R (+)	4.1 ± 4.0*	0.12 ± 0.10*
Racemic	4.1 ± 1.6*	0.21 ± 0.10

^∗0𝑥0𝑓𝑓1𝑎𝑃<.05 versus S(−). n = 8.