Lasting Developmental Effects of Neonatal Fentanyl Exposure in Preweanling Rats
Table 1
Early outcomes.
Measures
Groups
P
Fentanyl
Saline
Unoperated
Weight, mean (±SD), g:
PND 6
12 (±1)
11 (±2)
11 (±2)
>.05
PND 9
18 (±2)
16 (±3)
16 (±2)
>.05
Righting latency, median (IQR), sec:
PND 6
2 (1-2)
2 (2-2)
2 (2-2)
>.05
PND 9
1 (1–1.3)
1 (1-2)
1 (1–1.3)
>.05
Geotactic latency, median (IQR), sec:
PND 6
183 (152–183)
29 (20–145)
34 (12–48)
<.05*
PND 9
19 (13–27)
23 (11–44)
22 (12–48)
>.05
Locomotor activity score, median (IQR):
PND 6
1 (1-2)
2 (1–2.3)
1 (1-2)
>.05
PND 9
2 (1.8–3)
3 (2-3)
3 (2.8–3)
>.05
PND: postnatal day; IQR: interquartile range; P: significance for independent samples. Locomotor activity scores: 1: immobility and head down; 2: raises head up; 3: forepaws over borders; 4: climbs the borders. Fentanyl versus saline and fentanil versus unoperated (), both *.
