Table 4: Therapy of pulmonary hypertension: approved drugs (mod. [8]).

DrugDosageSide effect

BosentanEndothelin receptor antagonist2 × 62,5–125 mg/d poIncrease of liver enzymes edema
AmbrisentanSelective endothelin-A
Receptor-antagonist
1 × 5–10 mg/d poIncrease of liver enzymes
edema
SildenafilPDE-5 inhibitor3 × 20 mg/d poReflux esophagitis
TadalafilPDE-5 inhibitor1 × 40 mg/d poHeadache and pain in the limbs
IloprostProstacyclin-analog6–9 × 2,5/5 μg inhalativeHypotension and flush
TreprostinilProstacyclin-analog1,25–22,5 ng/kg/min s.c.Local pain