About this Journal Submit a Manuscript Table of Contents
Anesthesiology Research and Practice
Volume 2012 (2012), Article ID 878764, 6 pages
http://dx.doi.org/10.1155/2012/878764
Research Article

Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse

1Department of Anesthesiology, Seoul National University Hospital, No. 103, Daehang-no, Jongno-gu, Seoul 110-744, Republic of Korea
2Clinical Research Institute, Seoul National University Hospital, No. 103, Daehang-no, Jongno-gu, Seoul 110-744, Republic of Korea
3Department of Anesthesiology, Boramae City Hospital, 20 Boramae-ro 5-Gil, Dongjak-gu, Seoul 156-707, Republic of Korea

Received 28 October 2011; Revised 26 January 2012; Accepted 28 January 2012

Academic Editor: Ronald G. Pearl

Copyright © 2012 Solmon Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. B. Long, S. Rosenblum, and I. P. Grady, “Successful resuscitation of bupivacaine-induced cardiac arrest using cardiopulmonary bypass,” Anesthesia & Analgesia, vol. 69, no. 3, pp. 403–406, 1989. View at Scopus
  2. S. Reiz and S. Nath, “Cardiotoxicity of local anaesthetic agents,” British Journal of Anaesthesia, vol. 58, no. 7, pp. 736–746, 1986. View at Scopus
  3. C. W. Clarkson and L. M. Hondeghem, “Mechanism for bupivacaine depression of cardiac conduction: fast block of sodium channels during the action potential with slow recovery from block during diastole,” Anesthesiology, vol. 62, no. 4, pp. 396–405, 1985. View at Scopus
  4. N. A. Castle, “Bupivacaine inhibits the transient outward K+ current but not the inward rectifier in rat ventricular myocytes,” Journal of Pharmacology and Experimental Therapeutics, vol. 255, no. 3, pp. 1038–1046, 1990. View at Scopus
  5. H. S. Cho, J. J. Lee, I. S. Chung, B. S. Shin, J. A. Kim, and K. H. Lee, “Insulin reverses bupivacaine-induced cardiac depression in dogs,” Anesthesia & Analgesia, vol. 91, no. 5, pp. 1096–1102, 2000. View at Scopus
  6. E. U. M. Nyström, J. E. Heavner, and C. W. Buffington, “Blood pressure is maintained despite profound myocardial depression during acute bupivacaine overdose in pigs,” Anesthesia & Analgesia, vol. 88, no. 5, pp. 1143–1148, 1999. View at Publisher · View at Google Scholar
  7. P. Arlock, “Actions of three local anaesthetics: lidocaine, bupivacaine and ropivacaine on guinea pig papillary muscle sodium channels(Vmax),” Pharmacology and Toxicology, vol. 63, no. 2, pp. 96–104, 1988. View at Scopus
  8. H. Komai and A. J. Lokuta, “Interaction of bupivacaine and tetracaine with the sarcoplasmic reticulum Ca2+ release channel of skeletal and cardiac muscles,” Anesthesiology, vol. 90, no. 3, pp. 835–843, 1999. View at Scopus
  9. X. Sun and K. D. Garlid, “On the mechanism by which bupivacaine conducts protons across the membranes of mitochondria and liposomes,” Journal of Biological Chemistry, vol. 267, no. 27, pp. 19147–19154, 1992. View at Scopus
  10. J. T. Kim, C. W. Jung, and K. H. Lee, “The effect of insulin on the resuscitation of bupivacaine-induced severe cardiovascular toxicity in dogs,” Anesthesia & Analgesia, vol. 99, no. 3, pp. 728–733, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. S. N. Stehr, A. Pexa, S. Hannack et al., “Insulin effects on myocardial function and bioenergetics in L-bupivacaine toxicity in the isolated rat heart,” European Journal of Anaesthesiology, vol. 24, no. 4, pp. 340–346, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. L. Simon, N. Kariya, A. Edouard, D. Benhamou, and J. X. Mazoit, “Effect of bupivacaine on the isolated rabbit heart: developmental aspect on ventricular conduction and contractility,” Anesthesiology, vol. 101, no. 4, pp. 937–944, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Mio, N. Fukuda, Y. Kusakari, Y. Tanifuji, and S. Kurihara, “Bupivacaine attenuates contractility by decreasing sensitivity of myofilaments to Ca2+ in rat ventricular muscle,” Anesthesiology, vol. 97, no. 5, pp. 1168–1177, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. M. P. Gupta, I. R. Innes, and N. S. Dhalla, “Characterization of insulin receptors in cardiac sarcolemmal and sarcoplasmic reticular membranes,” Journal of Cardiovascular Pharmacology, vol. 10, no. 3, pp. 259–267, 1987. View at Scopus
  15. K. Zierler and F. S. Wu, “An early outward transient K+ current that depends on a preceding Na+ current and is enhanced by insulin,” Pflugers Archiv European Journal of Physiology, vol. 422, no. 3, pp. 267–272, 1992. View at Publisher · View at Google Scholar · View at Scopus
  16. N. A. Paradis, G. B. Martin, E. P. Rivers et al., “Coronary perfusion pressure and the return of spontaneous circulation in human cardiopulmonary resuscitation,” Journal of the American Medical Association, vol. 263, no. 8, pp. 1106–1113, 1990. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Lacombe, G. Blaise, D. Loulmet, and C. Hollmann, “Electrophysiologic effects of bupivacaine in the isolated rabbit heart,” Anesthesia & Analgesia, vol. 72, no. 1, pp. 62–69, 1991. View at Scopus
  18. D. M. Kotelko, S. M. Shnider, P. A. Dailey, et al., “Bupivacaine-induced cardiac arrhythmias in sheep,” Anesthesiology, vol. 60, no. 1, pp. 10–18, 1984.
  19. B. N. Singh and E. M. Williams, “Effect of altering potassium concentration on the action of lidocaine and diphenylhydantoin on rabbit atrial and ventricular muscle,” Circulation Research, vol. 29, no. 3, pp. 286–295, 1971. View at Scopus
  20. H. S. Cho, J. A. Kim, S. Lee, and K. H. Lee, “The influence of serum potassium change on bupivacaine-induced cardiac toxicity in dogs with normal serum potassium concentration,” Korean Journal of Anesthesiology, vol. 39, no. 1, pp. 119–123, 2000.
  21. H. S. Feldman, G. R. Arthur, and B. G. Covino, “Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog,” Anesthesia & Analgesia, vol. 69, no. 6, pp. 794–801, 1989. View at Scopus