Sugammadex-Enhanced Neuronal Apoptosis following Neonatal Sevoflurane Exposure in Mice

Figure 3

Cleaved caspase-3 activation in the retrosplenial cortex of the brain. Black dots indicate cleaved caspase-3-positive cells in the (a) nonanesthesia (NA), (b) sugammadex, (c, e) sevoflurane (SEVO), and (d, f) sugammadex + SEVO groups. Scale bars: 200 μm (a–d); 50 μm (e, f). Six hours of neonatal sevoflurane exposure increased the number of cleaved caspase-3-positive cells, indicating apoptosis. The intraperitoneal administration of sugammadex significantly enhanced neuronal apoptosis associated with neonatal 2% sevoflurane exposure.

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