Pregabalin Effect on Acute and Chronic Pain after Cardiac Surgery

Table 2

Postoperative analgesic use and pain intensity. Data reported as median (minimum, maximum). values for comparisons between study groups were calculated using the Kruskal-Wallis or Chi-square tests as appropriate. values for significance were adjusted to 0.05/12 = 0.0042 using Bonferroni correction for multiple comparisons.

Variable	Group 1 (control)	Group 2 (pregabalin 75 mg)	Group 3 (pregabalin 150 mg)
Intraoperative fentanyl (mcg)	200 (150, 350)	200 (100, 350)	200 (50, 300)	0.689
Intraoperative remifentanil (mcg)	420 (380, 600)	420 (360, 480)	400 (360, 500)	0.168
Boluses requested	12 (4, 74)	6 (0, 27)	4 (1, 26)	0.000
Boluses given	10 (4, 28)	6 (0, 14)	4 (1, 13)	0.000
VRS at 8 hours	4 (2, 6)	3 (3, 4)	3 (0, 6)	0.001
VRS at 24 hours	1 (0, 5)	1 (0, 4)	0 (0, 3)	0.007
VRS at 3 months	3 (2, 5)	2 (1, 3)	2 (1, 3)	0.000
Morphine use in first 8 hours (mg)	14 (12, 17)	13 (11, 16)	12 (11, 14)	0.000
Morphine use in first 24 hours (mg)	19.5 (16, 30)	16 (14, 22)	15 (12.5, 18)	0.000
Vomiting at 24 hours	6	4	3	0.535
Use of analgesics at 3 months	26	16	10	0.000
Sleep disturbance at 3 months	16	5	3	0.000