Injectable Anesthesia for Mice: Combined Effects of Dexmedetomidine, Tiletamine-Zolazepam, and Butorphanol

Table 2

Trials with dexmedetomidine and tiletamine-zolazepam (DTZ). Dexmedetomidine and tiletamine-zolazepam were administered IP and butorphanol was administered at 3 mg/kg SC. Data is reported in marginal means and standard error.

	Anesthetic duration (minutes)	Recovery time (minutes)	Anesthesia achieved (%)	Heart rate (bpm)	Respiratory rate (bpm)
Dexmedetomidine 0.4 mg/kg
Tiletamine-zolazepam
20 mg/kg	63 (±22)	279 (±25)	50% (3/6)	187 (±14)	128 (±3)
40 mg/kg	67 (±22)	240 (±25)	33% (2/6)	222 (±14)	136 (±3)
60 mg/kg	77 (±22)	240 (±25)	33% (1/3)	227 (±20)	135 (±4)
Dexmedetomidine 0.6 mg/kg
Tiletamine-zolazepam
20 mg/kg	23 (±16)	222 (±17)	67% (4/6)	229 (±14)	134 (±3)
40 mg/kg	73 (±13)	265 (±16)	100% (6/6)	209 (±14)	132 (±3)
60 mg/kg	47 (±22)	243 (±25)	67% (2/3)	193 (±20)	130 (±4)
Dexmedetomidine 0.8 mg/kg
Tiletamine-zolazepam
20 mg/kg	58 (±18)	253 (±20)	50% (3/6)	254 (±14)	145 (±3)
40 mg/kg	48 (±18)	286 (±35)	40% (2/5)	207 (±16)	130 (±3)
60 mg/kg	175 (±31)	404 (±35)	50% (1/2)	233 (±25)	125 (±5)