Injectable Anesthesia for Mice: Combined Effects of Dexmedetomidine, Tiletamine-Zolazepam, and Butorphanol

Table 4

Recommended dosages of dexmedetomidine, tiletamine-zolazepam, and butorphanol. Dosages recommended for use were determined based on anesthetic duration, induction, and recovery time, as well as safety, as measured by mortality. Increased dosages of dexmedetomidine and tiletamine-zolazepam resulted in an increasing trend of anesthetic duration and recovery times. Dexmedetomidine and tiletamine-zolazepam were administered IP and butorphanol was administered in all above listed trials at 3 mg/kg SC. Data are reported in predicted marginal means and standard error.

	Anesthetic duration (minutes)	Recovery time; (minutes)	Anesthesia achieved (%)	Heart rate (bpm)	Respiratory rate (bpm)
Dexmedetomidine 0.2 mg/kg
Tiletamine-zolazepam 20 mg/kg	73 (±16)	168 (±16)	100% (6/6)	191 (±12)	137 (±4)
Tiletamine-zolazepam 40 mg/kg	143 (±16)	217 (±16)	100% (6/6)	198 (±12)	137 (±4)
Dexmedetomidine 0.4 mg/kg
Tiletamine-zolazepam 20 mg/kg	110 (±16)	224 (±16)	100% (6/6)	202 (±12)	134 (±4)
Tiletamine-zolazepam 40 mg/kg	163 (±16)	273 (±16)	100% (6/6)	209 (±12)	134 (±4)