A Randomized Controlled Trial for Prevention of Postoperative Nausea and Vomiting after Laparoscopic Sleeve Gastrectomy: Aprepitant/Dexamethasone vs. Mirtazapine/Dexamethasone
Table 2
Postoperative nausea and vomiting among the studied groups in the first 24 h.
Variables
A/D group
M/D group
D group
value
Number of cases (0–2 h)
29
28
29
Number of nausea episodes (%)
4 (13.8)
3 (10.7)
5 (17.2)
§0.924
Grade of nausea, n (%)
I
0 (0)
1 (33.3)
0 (0)
§0.318
II
1 (25)
2 (66)
2 (40)
III
3 (75)
0 (0)
3 (60)
Number of vomiting episodes (%)
0 (0)a
3 (10.7)ab
6 (20.7)b
§0.029
PONV, n (%)
4 (13.8)
6 (21.4)
11 (37.9)
#0.092
Use of rescue antiemetic, n (%)
3 (10.3)
3 (10.7)
9 (31)
#0.060
Complete response, n (%)
26 (89.7)
25 (89.3)
20 (69)
#0.060
Number of cases (2–24 h)
26
25
20
Number of nausea episodes (%)
6 (23.1)ab
3 (12.0)a
11 (55.0)b
#0.005
Grade of nausea, n (%)
I
1 (16.7)
2 (66.7)
0 (0)
§0.061
II
3 (50)
1 (33.3)
4 (36.4)
III
2 (33.3)
0 (0)
7 (63.6)
Number of vomiting episodes (%)
1 (3.8)a
3 (12.0)ab
7 (35.0)b
§0.016
PONV, n (%)
7 (26.9)a
6 (24)a
18 (90.0)b
#<0.001
Use of rescue antiemetic, n (%)
3 (11.5)a
3 (12.0)a
14 (70.0)b
#<0.001
Complete response, n (%)
23 (88.8)a
22 (88)a
6 (30.0)b
#<0.001
Number of cases (0–24 h)
29
28
29
Number of nausea episodes (%)
10 (34.5)ab
6 (21.4)a
16 (55.2)b
#0.029
Grade of nausea, n (%)
I
1 (10)
3 (50)
0 (0)
§0.012
II
4 (40.0)
3 (50)
6 (37.5)
III
5 (50)ab
0 (0)a
10 (62.5)b
Number of vomiting episodes (%)
1 (3.4)a
6 (21.4)ab
13 (44.8)b
#0.001
PONV, n (%)
10 (34.5)a
11 (35.7)a
27 (93.1)b
#<0.001
Use of rescue antiemetic, n (%)
6 (20.7)a
6 (21.4)a
23 (79.3)b
#<0.001
Complete response, n (%)
23 (79.3)a
22 (78.6)a
6 (20.7)b
#<0.001
The values are presented as mean ± SD, number of patients (%), or median (Q1, Q3). #Chi-square test. §Fisher’s exact test. Labels (a, b, c) denotes homogenous groups depending on the post hoc Bonferroni test. Statistically significant. A/D group: aprepitant/dexamethasone group, M/D group: mirtazapine/dexamethasone group, D group: dexamethasone group, and PONV: postoperative nausea and vomiting.
