A Randomized Controlled Trial for Prevention of Postoperative Nausea and Vomiting after Laparoscopic Sleeve Gastrectomy: Aprepitant/Dexamethasone vs. Mirtazapine/Dexamethasone
Table 3
Postoperative findings among the studied groups.
Variables
A/D group (N = 29)
M/D group (N = 28)
D group (N = 29)
value
Sedation
Ramsay sedation scale (preoperative)
1.5 (0.5)a
2.3 (0.5)b
1.2 (0.4)a
^<0.001
Ramsay sedation scale (postoperative)
1.7 (0.8)a
2.9 (0.6)b
1.3 (0.5)a
^<0.001
Postoperative pain and analgesia
Pain score 0–2 hour
2.1 (0.7)a
2.2 (0.6)a
2.8 (0.7)b
^<0.001
Pain score 2–24 hour
2.3 (0.5)a
3.8 (0.4)b
4.3 (1.1)c
^<0.001
Time to first rescue analgesia (ketorolac) (min)
89.3 (21)a
77.9 (17.1)b
53.4 (13.4)c
^<0.001
Total dose of rescue analgesia (ketorolac), (mg) 0–24 hour
40.7 (17.7)a
59.3 (15.4)b
70.3 (15.7)c
^<0.001
Side effects
Headache, n (%)
2 (6.9)
2 (7.1)
1 (3.4)
§0.867
Dizziness, n (%)
3 (10.3)
1 (3.6)
2 (6.9)
§0.867
Dry mouth, n (%)
1 (3.4)
2 (7.1)
2 (6.9)
§0.867
Somnolence, n (%)
0 (0)
2 (7.1)
0 (0)
§0.103
Diarrhea, n (%)
1 (3.4)
0 (0)
0 (0)
§1.000
Any side effect, n (%)
5 (17.2)
6 (21.4)
3 (10.3)
§0.509
Satisfaction
Patient satisfaction score
5.4 (1.6)a
3.8 (1.4)b
2.7 (1.3)c
^<0.001
The values are presented as mean ± SD, number of patients (%), or median (Q1, Q3). ^ANOVA test. #Chi-square test. §Fisher’s exact test. Labels (a, b, c) denotes homogenous groups depending on the post hoc Bonferroni test. Statistically significant. A/D group: aprepitant/dexamethasone group, M/D group: mirtazapine/dexamethasone group, and D group: dexamethasone group.
