Efficacy of High-Dose Vitamin C Infusion on Outcomes in Sepsis Requiring Mechanical Ventilation: A Double-Blind Randomized Controlled Trial
Table 1
Baseline demographic and clinical characteristics between the study groups.
Variables
Group I (n = 20)
Group II (n = 20)
p value
Age (years)
53.0 ± 23.3
52.1 ± 18.8
^0.900
Sex (n, %)
Male
9 (45.0%)
12 (60.0%)
#0.342
Female
11 (55.0%)
8 (40.0%)
Body mass index (BMI) (kg/m2)
28.2 ± 5.9
28.7 ± 6.3
^0.810
APACHE II
23.2 ± 4.7
22.6 ± 5.4
^0.712
Time from ICU admission up to the diagnosis of sepsis (hours)
13.5 ± 3.1
13.4 ± 3.5
^0.888
Physiological variables at day 0 (randomization)
White blood cell count (WBCs) (x103/mL)
17.4 ± 6.5
17.0 ± 6.9
^0.855
Serum creatinine (mg/dL)
0.80 ± 0.27
0.90 ± 0.42
^0.380
Lactate (mmol/L)
3.6 ± 0.4
3.7 ± 0.5
^0.405
PaO2/FiO2 ratio
195.7 ± 98.8
201.1 ± 128.2
^0.883
Data were presented as mean and standard deviation or number and (%). APACHE: Acute Physiology and Chronic Health Evaluation; FiO2: fraction of inspired oxygen; PaO2: partial pressure of oxygen; SD: standard deviation; SOFA: sepsis-related organ failure assessment. ^Independent t-test, #chi-squared test, §Fisher's exact test.
