Efficacy of High-Dose Vitamin C Infusion on Outcomes in Sepsis Requiring Mechanical Ventilation: A Double-Blind Randomized Controlled Trial
Table 3
Clinical outcomes between the study groups.
Variables
Group I (n = 20)
Group II (n = 20)
value
Early VAP, number of episodes (%)
1(5.0%)
7(35.0%)
§0.044
Late VAP, number of episodes (%)
1(5.0%)
5(25%)
⌂0.182
SOFA score, mean ± SD
SOFA score (day 0)
12.1 ± 1.6
12.7 ± 2.1
⋀0.354
SOFA score (day 1)
8.8 ± 1.4
9.8 ± 1.8
⋀0.057
SOFA score (day 4)
5.2 ± 2.0
9.0 ± 2.6
⋀<0.001
SOFA score (day 7)
3.9 ± 2.9
10.5 ± 2.7
⋀<0.001
DSOFA (day 0–day 7)
−3.2 ± 2.8
0.8 ± 3.3
⋀<0.001
Plasma vitamin C level, mean ± SD
Plasma vitamin C level (day 0) (µmol/L)
21.4 ± 10.6
22.5 ± 12.3
⋀0.759
Plasma vitamin C level (day 1) (µmol/L)
297.7 ± 92.6
25.3 ± 12.4
⋀<0.001
Plasma vitamin C level (day 4) (µmol/L)
656.8 ± 125.6
26.3 ± 10.8
⋀<0.001
Plasma vitamin C level (day 7) (µmol/L)
109.8 ± 28.7
23.0 ± 10.8
⋀<0.001
GPX activity, Mean ± SD
GPX (day 0) (U/ml)
0.308 ± 0.172
0.327 ± 0.206
⋀0.760
GPX (day 1) (U/ml)
0.498 ± 0.174
0.387 ± 0.203
⋀0.071
GPX (day 4) (U/ml)
0.648 ± 0.295
0.408 ± 0.209
⋀0.005
GPX (day 7) (U/ml)
0.481 ± 0.292
0.275 ± 0.209
⋀0.014
CRP levels, mean ± SD
CRP (day 0) (mg/L)
253.3 ± 47.2
255.9 ± 48.5
⋀0.864
CRP (day 1) (mg/L)
232.0 ± 47.0
261.6 ± 48.4
⋀0.057
CRP (day 4) (mg/L)
175.9 ± 57.6
307.5 ± 74.4
⋀<0.001
CRP (day 7) (mg/L)
168.0 ± 57.4
314.7 ± 74.8
⋀<0.001
Mean of vasopressor therapy duration (hours)
55.8 ± 21.6
75.6 ± 33.3
⋀0.033
28-day mortality, n, (%)
3 (15.0%)
9 (45%)
⌂0.038
Ventilator-free days (days), median (IQR)
22 (21.0–23.0)
21.5 (20.3–22.0)
#0.084
ICU LOS (days), median (IQR)
9.0 (8.0–11.0)
13.5 (8.0–24.8)
#0.081
Data were presented as mean and standard deviation (SD), number and percentage or median, 1st& 3rd interquartile range. Significant. CRP: C-reactive protein; DSOFA: delta SOFA (change in SOFA score) (negative values indicate reduction); GPX: glutathione peroxidase; ICU: intensive care unit; ICU LOS: ICU length of stay; VAP: ventilator-associated pneumonia, ^independent t-test, ⌂chi-squared test, #Mann–Whitney U test, §Fisher’s exact test.
