Simulation-Based Analysis of Trial Design in Regional Anesthesia

Table 2

Median and interquartile range (IQR) of final effect size and its value across 1,000 simulated sequences of randomized controlled trials.

Scenario	Median effect size	IQR of median effect size	Median value	IQR of median value
Block vs. no block, baseline	0.78	0.73, 0.83	<0.001	<0.001, <0.001
Block vs. no block, lower alpha	0.78	0.73, 0.83	<0.001	<0.001, <0.001
Block vs. no block, higher power	0.78	0.73, 0.82	<0.001	<0.001, <0.001
Block vs. no block, assumed non-normality	0.78	0.73, 0.83	<0.001	<0.001, <0.001
Block vs. block, baseline	0.30	0.12, 0.37	<0.001	<0.001, 0.509
Block vs. block, lower alpha	0.24	0.13, 0.36	0.082	<0.001, 0.505
Block vs. block, higher power	0.27	0.11, 0.37	0.036	<0.001, 0.558
Block vs. block, assumed non-normality	0.28	0.12, 0.37	0.003	<0.001, 0.533

values of ≤0.05 were deemed statistically significant. IQR, interquartile range.