Tenofovir Nephrotoxicity: 2011 Update

Table 2

Biochemical features and time course of a case of tenofovir-associated Fanconi syndrome.

	Before tenofovir	After 4 years; of tenofovir	One month after tenofovir	Five months after Tenofovir
Serum
Creatinine (mg/dL)	0.96	1.5	1.3	0.9
Glucose (mg/dL)	97	88	94	79
Uric acid (mg/dL)	8.4	1.2	1.8	3.4
Potassium (mmol/L	4.2	4.5	4.1	No data
Calcium (mg/dL)	9.1	8.5	9.2	9.2
Phosphorus (mg/dL)	3.8	2	3.2	No data
Total proteins (g/dL)	No data	7.8	8.5	7.9
PTH (pg/mL)	No data	128	55	27
Alkaline phosphatase (UI/L)*	No data	271	242	154
Urine and calculated parameters
Glycosuria (mg/dL)	Negative	1000	No data	Negative
Proteinuria (mg/dL)	Negative	50	53	Negative
Tubular reabsorption of phosphate (%)	No data	34	59
Creatinine clearance (mL/min)	86	26	40	No data
Albuminuria/creatinine (mg/g)	10	937	303	No data
Light chains κ/λ (mg/dL)	No data	4.2/4.1	2.5/1.7	0.6/<0.4
ß-2 microglobulin (ug/24 h)	No data	4	4	No data

GGT<10 UI/L at all time points.