Associations between HIV Antiretroviral Therapy and the Prevalence and Incidence of Pregnancy in Rakai, Uganda

Table 5

Incidence of pregnancy, unadjusted and adjusted IRR among HIV+ women after initiating ART.

Characteristics	Number of women	Incident pregnancy/pyrs	Incidence/100 pyrs (95% CI)	IRR (95% CI)	Adjusted IRR (95% CI)
Overall	244	48/195.5	24.6 (18.1, 32.6)
Baseline and week 12 CD4
Both <100	18	1/14.69	6.8 (0.17, 37.92)	1.0	1.0
Both 100+	182	39/145.50	26.8 (19.06, 36.64)	3.94 (0.68, 22.70)	4.12 (0.75, 22.50)
Base CD4 <100, wk12 100+	44	8/35.38	22.6 (9.76, 44.55)	3.32 (0.50, 2.26)	3.24 (0.46, 22.60)
Age (years)
15–24	19	6/14.31	41.9 (15.39, 91.26)	1.0	1.0
25–34	133	34/103.94	32.7 (22.65, 45.71)	0.78 (0.44, 1.39)	0.82 (0.38, 1.77)
35–45	92	8/77.31	10.3 (4.47, 20.39)	0.25 (0.13, 0.46)	0.27 (0.15, 0.50)
Desire for more children
Both do not want	179	34/144.52	23.5 (16.29, 32.88)	1.0	1.0
Only male wants	35	6/28.88	20.8 (7.62, 45.23)	0.88 (0.33, 2.33)	0.81 (0.36, 1.84)
Only female wants	8	1/6.13	16.3 (0.41, 90.89)	0.69 (0.12, 4.12)	0.50 (0.09, 2.81)
Both want	22	7/16.04	43.6 (17.55, 89.92)	1.85 (0.84, 4.10)	1.07 (0.43, 2.63)
Marital status
Not married	142	23/117.13	19.6 (12.45, 29.46)	1.0	1.0
Married	102	25/78.44	31.9 (20.63, 47.05)	1.62 (0.81, 3.25)	1.41 (0.76, 2.59)
HIV status disclosure
Not to anybody	58	15/45.69	32.8 (18.37, 54.15)	1.0	1.0
Yes, to somebody	186	33/149.88	22.0 (15.16, 30.92)	0.67 (0.38, 1.19)	0.69 (0.36, 1.32)
* Family planning method
None	69	18/51.83	34.7 (20.58, 54.89)	1.0
Condom only	45	12/35.45	33.8 (17.49, 59.13)	0.97 (0.47, 2.00)
Other	11	2/8.34	24.0 (2.91, 86.67)	0.69 (0.16, 3.08)
* BMI at week 12
Under weight, <18.5	24	5/18.11	5 (8.96, 64.43)	1.0
Normal weight	139	28/113.83	24.5 (16.35, 35.55)	0.89 (0.29, 2.72)
Overweight/obese	33	5/27.23	18.4 (5.96, 42.85)	0.67 (0.14, 3.16)
* WHO stage at week 12
I & II	94	19/75.81	25.1 (15.09, 39.14)	1.0
III & IV	48	6/39.27	15.3 (5.61, 33.26)	0.61 (0.23, 1.63)

*Data not available on all the 244 women.