CD8+ T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4+ T Cells <200 Cell/μL: The DART Trial STI Substudy
Figure 2
Relationship between breadth of HIV-specific CD8+ T-cell recognition at STI/CT randomization and the duration of pre-ART randomization. This figure evaluates whether ART uptake for either 52 weeks or 76 weeks preceding randomization had any influence on the breadths of HIV-specific (a) CD8+IFNγ +, (b) CD8+Perforin+, or (c) CD8+IFNγ +Perforin+ T-cell responses. Individual HIV peptides were grouped together in pools according to HIV protein. HIV-specific T-cell recognition was evaluated against these pools that were based on consensus sequences of HIV-1 Gag clades A (92UG037) and D (94UG114); and consensus sequences of HIV-1 clade B (Nef, Tat, Vif, Rev, Vpr, Vpu, and Pol). HIV-specific responses to Gag (clades A and D) were considered concomitantly. Breadth was defined as the number of HIV protein pools recognised per individual. Horizontal bars represent medians and interquartile ranges.
