AIDS Research and Treatment

Clinical Study

Differences in Lipid Measurements by Antiretroviral Regimen Exposure in Cohorts from Asia and Australia

Table 3

Adjusted analyses for triglycerides, HDL-C, and total cholesterol : HDL-C ratio.**


Covariate	Mean difference in triglycerides mmol/L (95% CI)	Mean difference in HDL-C mmol/L (95% CI)	Mean difference in total cholesterol : HDL-C ratio (95% CI)

Regimen
NRTIs (+TDF) + NVP	Reference	Reference	Reference
NRTIs (+TDF) + EFV	0.17 (−0.19 to 0.53)	0.01 (−0.06 to 0.08)	0.16 (−0.16 to 0.47)
NRTIs + NVP	0.58 (0.29 to 0.87)	0.15 (0.08 to 0.21)	0.13 (−0.12 to 0.39)
NRTIs + EFV	0.64 (0.34 to 0.95)	0.09 (0.03 to 0.16)	0.29 (0.01 to 0.56)
NRTIs (+TDF) + PI(+ATV)	0.15 (−0.22 to 0.52)	−0.03 (−0.11 to 0.05)	0.29 (−0.04 to 0.62)
NRTIs (+TDF) + PI	1.06 (0.73 to 1.38)	−0.02 (−0.09 to 0.05)	0.66 (0.37 to 0.95)
NRTIs + PI(+ATV)	0.57 (0.24 to 0.90)	0.03 (−0.05 to 0.10)	0.34 (0.02 to 0.65)
NRTIs + PI	1.13 (0.83 to 1.43)	0.01 (−0.06 to 0.07)	0.75 (0.47 to 1.03)
	<0.001	<0.001	<0.001
Cohort
AHOD	Reference	Reference	Reference
TAHOD	0.33 (0.11 to 0.55)	0.04 (−0.01 to 0.09)	−0.16 (−0.40 to 0.08)
	0.003	0.146	0.187

Table shows independent effects of regimen and cohort variables in adjusted analyses. Since the interaction term between these variables was not significant, it was not included in the models. Figure 1 shows the interaction between regimen and cohort variables.
**Multivariable models were a priori adjusted for time on given regimen, Hepatitis B and/or C coinfections, age, gender, HIV RNA viral load copies/mL, CD4+ T-cell count, BMI, cumulative exposure to cART at the start of regimen, and HIV exposure category. AHOD: Australian HIV Observational Database, ATV: Atazanavir; cART: combinational antiretroviral therapy; CI: confidence interval; EFV: Efavirenz; HBV: Hepatitis B co-infection; HCV: Hepatitis C co-infection; IDU: Intravenous drug user; NNRTI: nonnucleoside reverse transcriptase inhibitors; NRTI: nucleoside reverse transcriptase inhibitors, NVP: nevirapine, PI: protease inhibitor, TAHOD: TREAT Asia HIV Observational Database; TDF: Tenofovir. Key. NRTIs are TDF based (NRTIs + TDF) or not (NRTIs) and PI as ATV based (PI + ATV) or not (PI).