Reduced Central Memory CD4+ T Cells and Increased T-Cell Activation Characterise Treatment-Naive Patients Newly Diagnosed at Late Stage of HIV Infection
Table 4
Multivariate logistic regression analysis of the association of demographic and HIV-related characteristics with late presentation.
Late presenters
P
(CD4 T cell 350 and/or AIDS-defining event)
AOR
95% CI
(a) Patients’ factors
Age, years
1.052
1.020–1.086
0.001
Risk group°
Heterosexual
2.435
1.251–4.741
0.009
Other
reference
Ethnicity
0.017
Migrants
2.543
1.178–5.486
Non-migrants
reference
(b) T-cells immune phenotypes
CD8+ T cells/L % (each unit more)
1.051
1.022–1.080
0.0001
CD4+CD127+ cells/L % (each unit more)
0.887
0.857–0.919
0.0001
CD8+CD95+ cells/L % (each unit more)
0.993
0.874–1.129
0.919
CD8+CD38+ cells/L % (each unit more)
1.038
0.989–1.089
0.132
CD8+CD38+CD45R0+ cells/L % (each unit more)
1.003
0.962–1.045
0.893
AOR: adjusted odds ratio; 95% CI, 95% confidence interval. was considered to denote statistical significance. Other: homosexual, intravenous drug users, and other risks groups.
