Table 1: Levels of hematological parameters in B6C3F1 mice.

AZT
dose
(mg/kg/d)
RBC count 
(106/mm3)
Hb content
 (g/dL)
MCV 
(μm3)
MCH 
(pg)
0-week11-week0-week11-week0-week11-week0-week11-week
MaleFemaleMaleFemaleMaleFemaleMaleFemaleMaleFemaleMaleFemaleMaleFemaleMaleFemale

09.9  
±  
  0.3
10.1  
±  
0.5
11.0a
±  
0.1
11.5  
±  
0.3
16.5  
±  
0.6
16.9  
±  
0.7
16.9  
± 
0.5
18.2  
±  
0.7
46.6  
±  
0.2
47.0  
±  
0.3
47.0  
± 
2.0
48.5  
±  
1.2
16.4  
±  
0.3
16.6  
±  
0.2
15.4  
±  
0.5
15.8a
±  
0.3

4008.7   
±  
  0.7
9.8  
± 
0.5
7.6  
± 
0.4
7.3a
± 
0.3
14.2  
± 
1.2
16.5  
±  
0.9
14.4  
±  
0.9
14.4  
±  
0.8
47.2  
±  
0.3
46.8  
±  
0.3
57.8a
±  
0.3
60.5a,b
±  
0.5
16.5  
±  
0.1
16.7  
±  
0.2
19.0a
±  
0.1
19.8a,b
±  
0.2

5008.6  
±  
0.7
10.0  
±  
0.7
7.7  
±  
0.1
8.4b
±  
0.1
14.1  
±  
1.2
16.5  
± 
1.2
14.8  
±  
0.3
16.5b
± 
0.2
47.8  
±  
0.3
46.7  
±  
0.2
58.5a
±  
0.5
60.3a,b
±  
0.3
16.4  
±  
0.1
16.4  
±  
0.2
19.2a
± 
0.1
19.7a,b
±  
0.1

6008.6  
±  
0.7
8.8  
± 
0.3
7.9  
±  
0.5
6.7a
±  
1.1
14.1  
± 
1.2
14.4  
±  
0.4
15.6  
± 
0.8
13.6  
±  
2.1
46.6  
±  
0.7
46.2  
±  
0.6
60.3a
±  
0.7
63.0a
±  
1.0
16.2  
±
0.2
16.2  
±  
0.1
19.7a
±  
0.2
20.6a
±  
0.4

aindicates a significant ( ) difference in hematological parameter at 11-week compared to 0-week for each sex.
bindicates a significant ( ) sex-based difference in hematological parameter in female mice compared to male counterparts at 11-week. Values are presented as the mean ± SEM ( –6). Also, a significant ( ) dose-related response was noted in the RBC count, Hb content, MCV, and MCH level in both sexes.