Table 2: Plasma lactate levels in B6C3F1 mice.

AZT dose (mg/kg/d)Plasma lactate level (mg/dL)
0-week12-week
MaleFemaleMaleFemale

0 71.5 ± 1.8a62.0 ± 3.2a,b
400 79.3 ± 8.0a56.0 ± 5.8a,b
500 57.9 ± 5.2a56.3 ± 4.2a
600 65.7 ± 4.3a52.7 ± 2.3a,b

aindicates a significant ( ) difference in plasma lactate levels at 12-week compared to 0-week for each sex.
bindicates a significant ( ) sex-related difference in plasma lactate levels in female mice compared to male counterparts at 12-week.
Values are presented as the mean ± SEM ( ).