Table 4: Relative mitochondrial DNA (mtDNA) copy number in the livers of B6C3F1 mice.

AZT dose (mg/kg/d)B6C3F1 mice
MaleFemale

0 ( ) ( )
400 ( ) ( )
500 ( ) ( )
600 ( ) ( )

The mtDNA copy number was based on quantitative real-time PCR measurements of D-loop concentration relative to the concentration of ΦX174RF added at a fixed concentration before DNA extraction. The numbers in parentheses indicate the number of animals in the group. Values are presented as the mean ± SEM (Standard error of the mean).