Table 1: The greatest initial NVP concentrations of every virus, IC50 (μM) of every virus and the increased NVP resistance compared to pNL4-3.

Virus no.Mutation patternsGreatest concentration of NVP (μM)IC50 (μM)Median fold of IC50 increased compared to pNL4-3 (±S.D.)

101Q-1K101Q/Y181C/H221Y1000 3740.8 (±314.1)
101Q-2K101Q/Y181C200 1490.9 (±354.4)
101Q-3K101Q/H221Y2 4.4 (±1.2)
101Q-4K101Q0.5 1.2 (±0.2)
179D-1V179D/Y181C/H221Y500 5090.6 (±744.6)
179D-2V179D/Y181C500 1413.0 (±269.8)
179D-3V179D/H221Y5 13.4 (±1.9)
179D-4V179D1.25 4.6 (±1.3)
103N-1K103N/Y181C/H221Y1000 5859.3 (±1648.2)
103N-2K103N/Y181C1000 2802.4 (±124.1)
103N-3K103N/H221Y50 139.2 (±8.2)
103N-4K103N25 63.8 (±3.1)
Con-11