Impact of Novel Resistance Profiles in HIV-1 Reverse Transcriptase on Phenotypic Resistance to NVP

Table 2

Contribution of H221Y, Y181C, H221Y/Y181C to an increased NVP resistance based on various mutation profiles.

Aimed mutation	Base mutation profile	Increased fold of IC50 (±S.D.)
H221Y	K101Q/Y181C	2.2 (±0.9)
H221Y	K101Q	3.2 (±0.3)
H221Y	V179D/Y181C	3.6 (±0.5)
H221Y	V179D	3.0 (±0.4)
H221Y	K103N/Y181C	2.1 (±0.5)
H221Y	K103N	2.2 (±0.1)
Y181C	K101Q/H221Y	759.1 (±41.9)
Y181C	K101Q	1297.0 (±289.1)
Y181C	V179D/H221Y	390.0 (±101.6)
Y181C	V179D	312.5 (±45.3)
Y181C	K103N/H221Y	41.9 (±8.4)
Y181C	K103N	47.9 (±4.2)
Y181C/H221Y	K101Q	3444.6 (±834.5)
Y181C/H221Y	V179D	1132.6 (±180.4)
Y181C/H221Y	K103N	100.6 (±32.5)