Table 2: Contribution of H221Y, Y181C, H221Y/Y181C to an increased NVP resistance based on various mutation profiles.

Aimed mutationBase mutation profileIncreased fold of IC50 (±S.D.)

H221YK101Q/Y181C2.2 (±0.9)
H221YK101Q3.2 (±0.3)
H221YV179D/Y181C3.6 (±0.5)
H221YV179D3.0 (±0.4)
H221YK103N/Y181C2.1 (±0.5)
H221YK103N2.2 (±0.1)
Y181CK101Q/H221Y759.1 (±41.9)
Y181CK101Q1297.0 (±289.1)
Y181CV179D/H221Y390.0 (±101.6)
Y181CV179D312.5 (±45.3)
Y181CK103N/H221Y41.9 (±8.4)
Y181CK103N47.9 (±4.2)
Y181C/H221YK101Q3444.6 (±834.5)
Y181C/H221YV179D1132.6 (±180.4)
Y181C/H221YK103N100.6 (±32.5)