Research Article
Nevirapine-Based Antiretroviral Therapy Impacts Artesunate and Dihydroartemisinin Disposition in HIV-Infected Nigerian Adults
Table 1
Comparison of pharmacokinetic parameters of artesunate and dihydroartemisinin.
| | Artesunate | Nevirapine Group, | Control Group, | P-value | | Mean (SD) | Mean (SD) |
| | (g/mL) | 108 (42) | 71 (57) | 0.15 | | (h)* | 1.0 (0.5–2.0)* | 1.0 (0.5–1.5)* | 0.67 | | Cl/F (L/h) | 1950 (543) | 2995 (1180) | 0.03 | | Vd/F (L) | 1162 (856) | 4525 (3535) | 0.01 | | (h) | 0.4 (0.3) | 1.1 (0.9) | 0.06 | | () | 105 (31) | 69 (26) | 0.02 |
| | Dihydroartemisinin | Mean (SD) | Mean (SD) | |
| | (μg/ml) | 298 (107) | 507 (429) | 0.15 | | (h)* | 1.0 (0.5–3.0)* | 1.5 (0.5–6.0)* | 0.11 | | Cl/F (L/h) | 1130 (425) | 980 (616) | 0.53 | | Vd/F (L) | 2405 (1077) | 4338 (2518) | 0.04 | | (h) | 1.6 (0.8) | 3.2 (1.4) | 0.004 | | () | 603 (218) | 883 (607) | 0.19 |
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*Presented as median (range).
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