Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1⁺ Puerto Ricans: 2006–2010

Table 2

Frequency of the 10 most prevalent resistance mutations in the HIV-1 reverse transcriptase gene, Puerto Rico 2006–2010.

	2006 (number of samples); % of resistant isolates			2007 (number of samples); % of resistant isolates			2008 (number of samples); % of resistant isolates			2009 (number of samples); % of resistant isolates			2010 (number of samples); % of resistant isolates
Mutation	Men; (411)	Women; (245)	Total*; (707)	Men; (384)	Women; (206)	Total; (608)	Men; (445)	Women; (245)	Total; (706)	Men; (224)	Women; (89)	Total; (340)	Men; (54)	Women; (36)	Total; (139)
M184V	44.3	49.0	45.5	43.2	41.3	41.6	27.0	33.9	29.2	24.6	32.6	25.9	7.4	16.7	10.1
M41L	20.7	25.3	22.2	16.9	18.9	17.4	11.2	11.0	11.2	8.0	15.7	10.6	3.7	13.9	7.9
K103N	20.9	21.6	21.5	15.9	24.3	18.8**	18.7	23.3	20.3	17.0	20.2	17.1	3.7	13.9	8.6
T215Y	17.5	20.8	19.0	15.4	15.0	15.0	9.4	9.0	9.2	7.1	4.5	6.5	1.9	8.3	4.3
D67N	20.9	16.7	18.5	16.7	13.1	15.0	9.0	10.2	9.6	7.6	12.4	9.1	3.7	8.3	5.0
V118I	13.9	17.1	14.7	13.8	10.7	12.5	7.4	7.3	7.6	12.1	9.0	11.2	3.7	19.4	7.2**
K70R	17.0	11	14.1**	15.4	10.7	13.3	9.9	8.6	9.5	5.8	12.4	7.4
L210W	10.0	13.1	10.9	9.1	8.7	8.9	6.3	6.9	6.5	4.5	3.4	4.4	1.9	11.1	3.6
K219Q	11.9	6.5	9.3**	9.9	6.8	8.6	6.1	5.3	5.7	5.4	1.1	3.8
T215F	7.3	5.7	6.6				4.3	3.7	4.0				3.7	5.6	4.3
T69N				3.6	6.8	4.6				3.6	3.4	3.5
G190A													5.6	5.6	4.3
K70R													3.7	5.6	3.6
E44D													0.0	8.3	3.6

*Includes the anonymous samples.
**Statistically significant difference observed between men and women.