Prevalence of Drug Resistance and Associated Mutations
in a Population of HIV-1+ Puerto Ricans: 2006–2010
Table 3
Frequency of the 10 most prevalent resistance mutations in the HIV-1 protease gene, Puerto Rico 2006–2010.
2006 (number of samples) % of resistant isolates
2007 (number of samples) % of resistant isolates
2008 (number of samples) % of resistant isolates
2009 (number of samples) % of resistant isolates
2010 (number of samples) % of resistant isolates
Mutation
Men (411)
Women (245)
Total* (707)
Men (384)
Women (206)
Total (608)
Men (445)
Women (245)
Total (706)
Men (224)
Women (89)
Total (340)
Men (54)
Women (36)
Total (139)
L63P**
75.7
75.1
74.3
71.9
68.0
70.6
72.8
65.7
70.0
70.5
69.7
70.0
64.8
66.7
66.9
M36I
20.2
26.5
23.2
27.1
25.2
26.0
18.0
27.4
21.7***
18.3
27.0
20.0
9.3
22.2
16.6
I13V
21.2
23.7
21.9
33.3
28.2
31.3
27.6
24.9
26.2
33.5
28.1
32.1
29.6
16.7
25.9
A71V
23.4
16.7
20.4***
18.0
14.1
16.8
9.9
12.7
11.3
9.4
9.0
10.0
V82F
16.3
20.4
18.4
M36L
17.5
18.8
17.5
A71T
15.1
13.1
14.9
12.8
13.1
12.6
9.8
13.5
10.6
9.3
5.6
7.9
L10I
16.1
10.6
13.7
14.3
12.6
13.5
15.1
13.9
14.7
11.6
20.2
14.4
D30N
11.0
14.3
11.6
L90M
13.4
7.8
11.2***
17.5
14.1
16.3
V77I
32.3
35.0
33.1
33.9
27.4
31.4
33.5
43.8
36.8
31.5
27.8
32.4
I62V
19.5
20.9
20.1
29.7
29.8
29.9
27.2
30.3
29.7
22.2
27.8
26.6
I93L
16.9
17.0
16.8
25.6
20.8
23.8
22.3
32.6
26.5
24.1
27.8
23.0
M46I
11.7
9.2
10.7
I15V
17.8
20.8
18.8
21.4
20.2
21.2
20.4
13.9
15.8
D60E
11.2
11.8
11.3
13.0
13.9
13.0
L19I
11.1
5.6
10.8
*Includes the anonymous samples.
**Includes all TruGene outputs for L63P, L63P/T, and L63T.
***Statistically significant difference observed between men and women.
