Ascertainment and Verification of End-Stage Renal Disease and End-Stage Liver Disease in the North American AIDS Cohort Collaboration on Research and Design
Table 3
Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of screening algorithms for end-stage renal disease (ESRD) and end-stage liver disease (ESLD) outcomes among participants in the randomly selected subcohort ( for ESRD and for ESLD).
Outcome
Screened positive ()
Verified case ()
Sensitivity
Specificity
PPV
NPV
End-stage renal disease
Overall (diagnosis OR laboratory)
76
62
100%
99%
82%
100%
Diagnosis criteria only
21
17
27%
100%
81%
98%
Laboratory criteria only
58
48
77%
100%
83%
99%
Diagnosis AND laboratory criteria
3
3
5%
100%
100%
98%
End-stage liver disease
Overall (diagnosis OR laboratory)
154
41
100%
95%
27%
100%
Diagnosis criteria only
135
39
95%
96%
29%
100%
Laboratory criteria only
36
8
20%
99%
22%
99%
Diagnosis AND laboratory criteria
17
6
15%
100%
35%
99%
Diagnosis of ascites, SBP, or variceal hemorrhagea
