Anaemia and Iron Homeostasis in a Cohort of HIV-Infected Patients: A Cross-Sectional Study in Ghana
Table 3
Immunological, haematological, and biochemical profiles of the study population stratified by anaemia status.
Parameter
Anaemia ()
No anaemia ()
value
Age (yrs)
36.87 ± 11.25
39.51 ± 9.40
0.0924
Immunological profile (mean ± SD)
CD4 (cells/mm3)
264.50 ± 98.40
476.80 ± 164.30
<0.0001
CD3 (cells/mm3)
1029.00 ± 485.20
1422.00 ± 559.90
<0.0001
CD4/CD3
0.23 ± 0.04
0.34 ± 0.13
<0.0001
WBC (103/μL)
5.06 ± 2.01
5.29 ± 1.18
0.4585
Haematological profile (mean ± SD)
Hb (g/dL)
9.32 ± 1.17
12.38 ± 1.06
<0.0001
RBC (106/μL)
3.43 ± 0.52
3.99 ± 0.54
0.5029
HCT (%)
28.89 ± 3.56
36.91 ± 3.24
<0.0001
MCV (fL)
85.41 ± 12.13
93.81 ± 10.89
<0.0001
MCH (pg)
28.39 ± 5.30
32.85 ± 4.62
<0.0001
MCHC (g/dL)
33.24 ± 3.21
35.05 ± 2.56
0.0017
RDW-CV
16.61 ± 2.16
14.73 ± 1.34
<0.0001
RDW-SD
52.59 ± 8.49
52.07 ± 6.88
0.3865
PLT (103/μL)
251.50 ± 91.12
239.40 ± 74.56
0.3357
Biochemical profile (mean ± SD)
Iron (μmol/L)
8.93 ± 3.99
15.09 ± 6.52
0.0019
Ferritin (μg/L)
228.70 ± 56.48
270.10 ± 39.21
0.0021
Transferrin (mg/dL)
229.00 ± 55.13
196.10 ± 24.23
<0.0001
TIBC (μg/dL)
290.80 ± 70.02
249.10 ± 30.77
<0.0001
% TSAT
18.87 ± 8.15
35.54 ± 15.83
0.0002
Data are presented as mean ± SD. values < 0.05 were considered significant. WBC = White Blood Cells, Hb = haemoglobin, RBC = Red Blood Cells, HCT = haematocrit, MCV = Mean Cell Volume, MCH = Mean Cell Haemoglobin, MCHC = Mean Cell Haemoglobin Concentration, RDW-CV = Red Cell Distribution Width-Cumulative Variance, RDW-SD = Red Cell Distribution Width-Standard Deviation, PLT = platelets, TIBC = Total Iron Binding Capacity, TSAT = transferrin saturation, and HAART = Highly Active Antiretroviral Therapy.
