Review Article
Pharmacokinetic, Pharmacogenetic, and Other Factors Influencing CNS Penetration of Antiretrovirals
Table 3
Some drugs that are affected by host pharmacogenetics and the resultant effect.
| Antiretroviral drug | Enzyme involved | Effect |
| Efavirenz | CYP2B6 | Increase in efavirenz concentrations and increased risk of discontinuation [50–56] | Nevirapine | CYP2B6 | Increase in nevirapine plasma concentrations and increase hypersensitivity adverse effect associated with nevirapine [57–60] | Atazanavir | UGT1A1 | Hyperbilirubinemia (indirect plasma bilirubin increase) and jaundice [157–160] | Tenofovir | ABCC2, ABCC4 | Renal function decline [161–163] | Abacavir | HLA-B5701 | Hypersensitivity associated with abacavir [164–167] |
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