The Palatability of Lopinavir and Ritonavir Delivered by an Innovative Freeze-Dried Fast-Dissolving Tablet Formulation

Table 1

Schedule for the 23-h consumption test sessions of water (W) and milk (MS) alone, with placebo FDT− and with FDT+ and body-weight-adjusted (BW) and full-strength 42% ethanol (EtOH) with and without LPV/r.

	Day 1	Day 2	Day 3	Day 4	Day 5	Day 6	Day 7	Day 8	Day 9	Day 10
Rat 1	W	W + FDT+	W + FDT−	MS	MS + FDT−	MS + FDT+	BW 42% EtOH + LPV/r	BW 42% EtOH	42% EtOH + LPV/r	42% EtOH
Rat 2	W + FDT+	W + FDT−	MS	MS + FDT−	MS + FDT+	BW 42% EtOH + LPV/r	BW 42% EtOH	W	42% EtOH	42% EtOH + LPV/r
Rat 3	W + FDT−	MS	MS + FDT−	MS + FDT+	BW 42% EtOH + LPV/r	BW 42% EtOH	W	W + FDT+	42% EtOH + LPV/r	42% EtOH
Rat 4	MS	MS + FDT−	MS + FDT+	BW 42% EtOH + LPV/r	BW 42% EtOH	W	W + FDT+	W + FDT−	42% EtOH	42% EtOH + LPV/r
Rat 5	MS + FDT−	MS + FDT+	BW 42% EtOH + LPV/r	BW 42% EtOH	W	W + FDT+	W + FDT−	MS	42% EtOH + LPV/r	42% EtOH
Rat 6	MS + FDT+	BW 42% EtOH + LPV/r	BW 42% EtOH	W	W + FDT+	W + FDT−	MS	MS + FDT−	42% EtOH	42% EtOH + LPV/r
Rat 7	BW 42% EtOH + LPV/r	BW 42% EtOH	W	W + FDT+	W + FDT−	MS	W + FDT−	MS + FDT+	42% EtOH + LPV/r	42% EtOH
Rat 8	BW 42% EtOH	W	W + FDT+	W + FDT−	MS	MS + FDT−	MS + FDT+	BW 42% EtOH + LPV/r	42% EtOH	42% EtOH + LPV/r