Table 2: Anti-CD6 SRCR-D1 mAbs and functional effects.

Clone Functional response Cross-link Author BLTP6a, UMCD6 and MT502 Block T-cell Ag dependant activation No [18] 161.8 Induces Erk1/2 activation Yes [37] IorT1, 2H1, T12, 6D3, Dako-CD6 Enhance anti-CD3, anti-CD28 and PMA T cell proliferation Yes [70, 71] Ior T1 Protects B-CLL from anti-IgM apoptosis Yes [25] UMCD6 Blocks T-cell/keratinocyte interaction No [18]