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Volume 2012 (2012), Article ID 505842, 9 pages
A Synoviocyte Model for Osteoarthritis and Rheumatoid Arthritis: Response to Ibuprofen, Betamethasone, and Ginger Extract—A Cross-Sectional In Vitro Study
1Department of Rheumatology, The Parker Institute, Copenhagen University Hospital Bispebjerg and Frederiksberg,
Nordre Fasanvej 57, 2000 Frederiksberg, Denmark
2Institute for Informatics and Mathematical Modelling, Technical University of Denmark, 2800 Lyngby, Denmark
3Department of Orthopaedic Surgery, Copenhagen University Hospital Bispebjerg and Frederiksberg, 2000 Frederiksberg, Denmark
4School of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 København Ø, Denmark
5Faculty of Health Science, University of Copenhagen, 2200 Copenhagen N, Denmark
6Center for Sensory-Motor Interaction, Aalborg University, 9220 Aalborg, Denmark
Received 3 August 2012; Revised 26 November 2012; Accepted 11 December 2012
Academic Editor: Marco Amedeo Cimmino
Copyright © 2012 Søren Ribel-Madsen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Y. Vasilopoulos, V. Gkretsi, M. Armaka, V. Aidinis, and G. Kollias, “Actin cytoskeleton dynamics linked to synovial fibroblast activation as a novel pathogenic principle in TNF-driven arthritis,” Annals of the Rheumatic Diseases, vol. 66, no. 3, pp. iii23–iii28, 2007.
- D. Kontoyiannis and G. Kollias, “Fibroblast biology. Synovial fibroblasts in rheumatoid arthritis: leading role or chorus line?” Arthritis Research, vol. 2, no. 5, pp. 342–343, 2000.
- U. Müller-Ladner, J. Kriegsmann, B. N. Franklin et al., “Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice,” American Journal of Pathology, vol. 149, no. 5, pp. 1607–1615, 1996.
- J. C. Fernandes, J. Martel-Pelletier, and J. P. Pelletier, “The role of cytokines in osteoarthritis pathophysiology,” Biorheology, vol. 39, no. 1-2, pp. 237–246, 2002.
- R. Bucala, C. Ritchlin, R. Winchester, and A. Cerami, “Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts,” Journal of Experimental Medicine, vol. 173, no. 3, pp. 569–574, 1991.
- M. N. Farahat, G. Yanni, R. Poston, and G. S. Panayi, “Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis,” Annals of the Rheumatic Diseases, vol. 52, no. 12, pp. 870–875, 1993.
- P. Barland, A. B. Novikoff, and D. Hamerman, “Electron microscopy of the human synovial membrane,” The Journal of Cell Biology, vol. 14, pp. 207–220, 1962.
- Y. Okada, I. Nakanishi, and K. Kajikawa, “Ultrastructure of the mouse synovial membrane. Development and organization of the extracellular matrix,” Arthritis and Rheumatism, vol. 24, no. 6, pp. 835–843, 1981.
- Z. Szekanecz and A. E. Koch, “Cell-cell interactions in synovitis. Endothelial cells and immune cell migration,” Arthritis Research, vol. 2, no. 5, pp. 368–373, 2000.
- K. B. van Landuyt, E. A. Jones, D. McGonagle, F. P. Luyten, and R. J. Lories, “Flow cytometric characterization of freshly isolated and culture expanded human synovial cell populations in patients with chronic arthritis,” Arthritis Research and Therapy, vol. 12, no. 1, article R15, 2010.
- F. C. Arnett, S. M. Edworthy, D. A. Bloch et al., “The American rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis,” Arthritis and Rheumatism, vol. 31, no. 3, pp. 315–324, 1988.
- R. Altman, E. Asch, and D. Bloch, “Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee,” Arthritis and Rheumatism, vol. 29, no. 8, pp. 1039–1052, 1986.
- R. Altman, G. Alarcon, D. Appelrouth et al., “The American college of rheumatology criteria for the classification and reporting of osteoarthritis of the hip,” Arthritis and Rheumatism, vol. 34, no. 5, pp. 505–514, 1991.
- D. G. Palmer, Y. Selvendran, C. Allen, P. A. Revell, and N. Hogg, “Features of synovial membrane identified with monoclonal antibodies,” Clinical and Experimental Immunology, vol. 59, no. 3, pp. 529–538, 1985.
- N. E. Zanchi, M. A. de Siqueira Filho, V. Felitti, H. Nicastro, F. M. Lorenzeti, and A. H. Lancha, “Glucocorticoids: extensive physiological actions modulated through multiple mechanisms of gene regulation,” Journal of Cellular Physiology, vol. 224, no. 2, pp. 311–315, 2010.
- T. G. Kantor, “Ibuprofen,” Annals of Internal Medicine, vol. 91, pp. 877–882, 1979.
- J. Y. Vanderhoek, S. L. Ekborg, and J. M. Bailey, “Effects of cell growth, differentiation, and transformation: clinical involvement of leukotrienes. Nonsteroidal anti-inflammatory drugs stimulate 15-lipoxygenase/leukotriene pathway in human polymorphonuclear leukocytes,” Journal of Allergy and Clinical Immunology, vol. 74, no. 3, pp. 412–417, 1984.
- J. R. Yoffe, “Effects of inflammatory agents on endothelial lysosomal fragility and their inhibition by antiinflammatory drugs,” British Journal of Pharmacology, vol. 72, no. 4, pp. 603–608, 1981.
- R. Grzanna, L. Lindmark, and C. G. Frondoza, “Ginger—an herbal medicinal product with broad anti-inflammatory actions,” Journal of Medicinal Food, vol. 8, no. 2, pp. 125–132, 2005.
- K. L. Kellar, R. R. Kalwar, K. A. Dubois, D. Crouse, W. D. Chafin, and B. E. Kane, “Multiplexed fluorescent bead-based immunoassays for quantitation of human cytokines in serum and culture supernatants,” Cytometry, vol. 45, no. 1, pp. 27–36, 2001.
- J. Dasso, J. Lee, H. Bach, and R. G. Mage, “A comparison of ELISA and flow microsphere-based assays for quantification of immunoglobulins,” Journal of Immunological Methods, vol. 263, no. 1-2, pp. 23–33, 2002.
- S. A. Cohen, K. M. de Antonis, and D. P. Michaud, “Compositional protein analysis using 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate, a novel derivatization reagent,” in Techniques in Protein Chemistry, R. H. Angeletti, Ed., pp. 289–298, Academic Press, San Diego, Calif, USA, 1993.
- P. Armitage, G. Berry, and J. N. S. Matthews, Statistical Methods in Medical Research, chapter 8,13, Blackwell Science, Oxford, UK, 4th edition, 2002.
- C. H. Evans, D. C. Mears, and J. L. Cosgrove, “Release of neutral proteinases from mononuclear phagocytes and synovial cells in response to cartilaginous wear particles in vitro,” Biochimica et Biophysica Acta, vol. 677, no. 2, pp. 287–294, 1981.
- M. Jutel, M. Akdis, and C. A. Akdis, “Histamine, histamine receptors and their role in immune pathology,” Clinical and Experimental Allergy, vol. 39, no. 12, pp. 1786–1800, 2009.
- C. G. Frondoza, A. Sohrabi, A. Polotsky, P. V. Phan, D. S. Hungerford, and L. Lindmark, “An in vitro screening assay for inhibitors of proinflammatory mediators in herbal extracts using human synoviocyte cultures,” In Vitro Cell Developmental Biology—Animal, vol. 40, no. 3-4, pp. 95–101, 2004.
- P. V. Phan, A. Sohrabi, A. Polotsky, D. S. Hungerford, L. Lindmark, and C. G. Frondoza, “Ginger extract components suppress induction of chemokine expression in human synoviocytes,” Journal of Alternative and Complementary Medicine, vol. 11, no. 1, pp. 149–154, 2005.
- R. D. Altman and K. C. Marcussen, “Effects of a ginger extract on knee pain in patients with osteoarthritis,” Arthritis and Rheumatism, vol. 44, no. 11, pp. 2531–2538, 2001.
- H. Bliddal, A. Rosetzsky, P. Schlichting et al., “A randomized, placebo-controlled, cross-over study of ginger extracts and Ibuprofen in osteoarthritis,” Osteoarthritis and Cartilage, vol. 8, no. 1, pp. 9–12, 2000.
- J. L. Funk, J. B. Frye, J. N. Oyarzo, and B. N. Timmermann, “Comparative effects of two gingerol-containing Zingiber officinale extracts on experimental rheumatoid arthritis,” Journal of Natural Products, vol. 72, no. 3, pp. 403–407, 2009.
- F. Jamali and C. M. Kunz-Dober, “Pain-mediated altered absorption and metabolism of ibuprofen: an explanation for decreased serum enantiomer concentration after dental surgery,” British Journal of Clinical Pharmacology, vol. 47, no. 4, pp. 391–396, 1999.
- J. S. Walker and J. J. Carmody, “Experimental pain in healthy human subjects: gender differences in nociception and in response to ibuprofen,” Anesthesia and Analgesia, vol. 86, no. 6, pp. 1257–1262, 1998.