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Linked References

1. J. M. H. Moll and V. Wright, “Psoriatic arthritis,” Seminars in Arthritis and Rheumatism, vol. 3, no. 1, pp. 55–78, 1973. View at Publisher · View at Google Scholar · View at Scopus
2. R. M. Grossman, J. Krueger, D. Yourish et al., “Interleukin 6 is expressed in high levels of psoriatic skin and stimulates proliferation of cultured human keratinocytes,” Proceedings of the National Academy of Sciences of the United States of America, vol. 86, no. 16, pp. 6367–6371, 1989. View at Scopus
3. P. Neuner, A. Urbanski, F. Trautinger et al., “Increased IL-6 production by monocytes and keratinocytes in patients with psoriasis,” Journal of Investigative Dermatology, vol. 97, no. 1, pp. 27–33, 1991. View at Scopus
4. K. Turksen, T. Kupper, L. Degenstein, I. Williams, and E. Fuchs, “Interleukin 6: Insights to its function in skin by overexpression in transgenic mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 11, pp. 5068–5072, 1992. View at Publisher · View at Google Scholar · View at Scopus
5. E. F. Wagner, H. B. Schonthaler, J. Guinea-Viniegra, and E. Tschachler, “Psoriasis: what we have learned from mouse models,” Nature Reviews Rheumatology, vol. 6, no. 12, pp. 704–714, 2010. View at Publisher · View at Google Scholar · View at Scopus
6. H. Mizutani, Y. Ohmoto, T. Mizutani, M. Murata, and M. Shimizu, “Role of increased production of monocytes TNF-α, IL-1β and IL-6 in psoriasis: relation to focal infection, disease activity and responses to treatments,” Journal of Dermatological Science, vol. 14, no. 2, pp. 145–153, 1997. View at Publisher · View at Google Scholar · View at Scopus
7. F. Atzeni, D. Ventura, A. Batticciotto, L. Boccassini, and P. Sarzi-Puttini, “Interleukin 6 blockade: tocilizumab in psoriatic arthritis,” The Journal of Rheumatology, vol. 89, pp. 97–99, 2012.
8. T. Tanaka, A. Ogata, and M. Narazaki, “Tocilizumab for the treatment of rheumatoid arthritis,” Expert Review of Clinical Immunology, vol. 6, no. 6, pp. 843–854, 2010. View at Publisher · View at Google Scholar · View at Scopus
9. T. Tanaka, Y. Kuwahara, Y. Shima et al., “Successful treatment of reactive arthritis with a humanized anti-interleukin-6 receptor antibody, tocilizumab,” Arthritis Care and Research, vol. 61, no. 12, pp. 1762–1764, 2009. View at Publisher · View at Google Scholar · View at Scopus
10. L. Brulhart, M. J. Nissen, P. Chevallier, and C. Gabay, “Tocilizumab in a patient with ankylosing spondylitis and Crohn's disease refractory to TNF antagonists,” Joint Bone Spine, vol. 77, no. 6, pp. 625–626, 2010. View at Publisher · View at Google Scholar · View at Scopus
11. J. C. Henes, M. Horger, I. Guenaydin, L. Kanz, and I. Koetter, “Mixed response to tocilizumab for ankylosing spondylitis,” Annals of the Rheumatic Diseases, vol. 69, no. 12, pp. 2217–2218, 2010. View at Publisher · View at Google Scholar · View at Scopus
12. D. Wendling, M. Bossert, and C. Prati, “Short-term effect of IL-6 inhibition in spondylarthritis,” Joint Bone Spine, vol. 77, no. 6, pp. 624–625, 2010. View at Publisher · View at Google Scholar · View at Scopus
13. Y. Shima, T. Tomita, T. Ishii et al., “Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorated clinical symptoms and MRI findings of a patient with ankylosing spondylitis,” Modern Rheumatology, vol. 21, no. 4, pp. 436–439, 2011. View at Publisher · View at Google Scholar · View at Scopus
14. J. D. Cohen, R. Ferreira, and C. Jorgensen, “Ankylosing spondylitis refractory to tumor necrosis factor blockade responds to tocilizumab,” Journal of Rheumatology, vol. 38, no. 7, p. 1527, 2011. View at Publisher · View at Google Scholar · View at Scopus
15. J. Dudler and B. Aubry-Roziier, “Tocilizumab in axial spondylarthropathies: about 18 cases,” The Annals of The Rheumatic Diseases, vol. 70, supplement 3, p. 128, 2011.
16. N. Del Castillo Piñol, L. Gossec, L. Sparsa, C. Roux, and M. Dougados, “Tocilizumab for treatment of refractory spondyloarthritis: report of 5 patients,” The Annals of The Rheumatic Diseases, vol. 70, supplement 3, p. 34, 2011.
17. F. K. Lekpa, C. Poulain, D. Wendling, et al., “Is IL-6 an appropriate target to treat spondyloarthritis patients refractory to anti-TNF therapy? a multicentre retrospective observational study,” Arthritis Research & Therapy, vol. 14, no. 2, p. R53, 2012.
18. J. Sieper, B. Porter-Brown, L. Thompson, O. Harari, and M. Dougados, “Tocilizumab (TCZ) is not effective for the treatment of ankylosing spondylitis (AS): results of phase 2, international, multicenter, randomized, double-blind, placebo-controlled trial,” The Annals of The Rheumatic Diseases, vol. 71, supplement 3, p. 110, 2012.
19. J. Sieper, R. D. Inman, S. Badalamenti, A. Radin, and J. Braun, “Sarilumab for the treatment of ankylosing spondylitis: results of phase 2, randomized double-blind, placebo-controlled, international study (ALIGN),” The Annals of The Rheumatic Diseases, vol. 71, supplement 3, p. 111, 2012.
20. A. Ogata, N. Umegaki, I. Katayama, A. Kumanogoh, and T. Tanaka, “Psoriatic arthritis in two patients with an inadequate response to treatment with tocilizumab,” Joint Bone Spine, vol. 79, no. 1, pp. 85–87, 2012.
21. S. Laurent, J. M. Le Parc, T. Clérici, M. Bréban, and E. Mahé, “Onset of psoriasis following treatment with tocilizumab,” British Journal of Dermatology, vol. 163, no. 6, pp. 1364–1365, 2010. View at Publisher · View at Google Scholar · View at Scopus
22. D. Wendling, H. Letho-Gyselinck, X. Guillot, and C. Prati, “Psoriasis onset with tocilizumab treatment for rheumatoid arthritis,” The Journal of Rheumatology, vol. 39, no. 3, p. 657, 2012.
23. P. Costello, B. Bresnihan, C. O'Farrelly, and O. Fitzgerald, “Predominance of CD8+ T lymphocytes in psoriatic arthritis,” Journal of Rheumatology, vol. 26, no. 5, pp. 1117–1124, 1999. View at Scopus
24. O. FitzGerald and R. Winchester, “Psoriatic arthritis: from pathogenesis to therapy,” Arthritis Research and Therapy, vol. 11, no. 1, article no. 214, 2009. View at Publisher · View at Google Scholar · View at Scopus
25. D. Kontoyiannis, M. Pasparakis, T. T. Pizarro, F. Cominelli, and G. Kollias, “Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU- rich elements: implications for joint and gut-associated immunopathologies,” Immunity, vol. 10, no. 3, pp. 387–398, 1999. View at Scopus
26. D. Kontoyiannis, G. Boulougouris, M. Manoloukos et al., “Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease,” Journal of Experimental Medicine, vol. 196, no. 12, pp. 1563–1574, 2002. View at Publisher · View at Google Scholar · View at Scopus
27. P. Mease, M. C. Genovese, G. Gladstein et al., “Abatacept in the treatment of patients with psoriatic arthritis: results of a six-month, multicenter, randomized, double-blind, placebo-controlled, phase II trial,” Arthritis and Rheumatism, vol. 63, no. 4, pp. 939–948, 2011. View at Publisher · View at Google Scholar · View at Scopus
28. J. M. Kremer, R. Westhovens, M. Leon et al., “Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig,” New England Journal of Medicine, vol. 349, no. 20, pp. 1907–1915, 2003. View at Publisher · View at Google Scholar · View at Scopus
29. F. A. Harding and J. P. Allison, “CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help,” Journal of Experimental Medicine, vol. 177, no. 6, pp. 1791–1796, 1993. View at Scopus
30. O. Boyman, H. P. Hefti, C. Conrad, B. J. Nickoloff, M. Suter, and F. O. Nestle, “Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-α,” Journal of Experimental Medicine, vol. 199, no. 5, pp. 731–736, 2004. View at Publisher · View at Google Scholar · View at Scopus
31. R. A. Clark, “Skin-resident T cells: the ups and downs of on site immunity,” Journal of Investigative Dermatology, vol. 130, no. 2, pp. 362–370, 2010. View at Publisher · View at Google Scholar · View at Scopus
32. S. Maeda, Y. Hayami, T. Naniwa, and R. Ueda, “The Th17/IL-23 axis and natural immunity in psoriatic arthritis,” International Journal of Rheumatology, vol. 2012, Article ID 539683, 8 pages, 2012. View at Publisher · View at Google Scholar
33. H. Park, Z. Li, X. O. Yang et al., “A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17,” Nature Immunology, vol. 6, no. 11, pp. 1133–1141, 2005. View at Publisher · View at Google Scholar · View at Scopus
34. M. A. Lowes, T. Kikuchi, J. Fuentes-Duculan et al., “Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells,” Journal of Investigative Dermatology, vol. 128, no. 5, pp. 1207–1211, 2008. View at Publisher · View at Google Scholar · View at Scopus
35. S. M. Sa, P. A. Valdez, J. Wu et al., “The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis,” Journal of Immunology, vol. 178, no. 4, pp. 2229–2240, 2007. View at Scopus
36. Y. Zheng, D. M. Danilenko, P. Valdez et al., “Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis,” Nature, vol. 445, no. 7128, pp. 648–651, 2007. View at Publisher · View at Google Scholar · View at Scopus
37. J. R. Chan, W. Blumenschein, E. Murphy et al., “IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis,” Journal of Experimental Medicine, vol. 203, no. 12, pp. 2577–2587, 2006. View at Publisher · View at Google Scholar · View at Scopus
38. E. Bettelli, Y. Carrier, W. Gao et al., “Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells,” Nature, vol. 441, no. 7090, pp. 235–238, 2006. View at Publisher · View at Google Scholar · View at Scopus
39. D. D. O. 'Rielly and P. Rahman, “Genetics of susceptibility and treatment response in psoriatic arthritis,” Nature Reviews Rheumatology, vol. 7, no. 12, pp. 718–732, 2011.
40. R. Scarpa, A. Del Puente, C. Di Girolamo, G. Della Valle, E. Lubrano, and P. Oriente, “Interplay between environmental factors, articular involvement, and HLA-B27 in patients with psoriatic arthritis,” Annals of the Rheumatic Diseases, vol. 51, no. 1, pp. 78–79, 1992. View at Scopus
41. E. Dika, F. Bardazzi, R. Balestri, and H. Maibach, “Environmental factors and psoriasis1,” Current Problems in Dermatology, vol. 35, pp. 118–135, 2007. View at Publisher · View at Google Scholar · View at Scopus
42. C. Ritchlin, “Psoriatic disease—from skin to bone,” Nature Clinical Practice Rheumatology, vol. 3, no. 12, pp. 698–706, 2007. View at Publisher · View at Google Scholar · View at Scopus
43. I. Olivieri, A. Padula, S. D'Angelo, and R. Scarpa, “Role of trauma in psoriatic arthritis,” Journal of Rheumatology, vol. 35, no. 11, pp. 2085–2087, 2008. View at Publisher · View at Google Scholar · View at Scopus
44. E. W. Rosenberg, P. W. Noah, and R. B. Skinner Jr, “Microorganisms and psoriasis,” Journal of the National Medical Association, vol. 86, no. 4, pp. 305–310, 1994.
45. C. Gota and L. Calabrese, “Induction of clinical autoimmune disease by therapeutic interferon-α,” Autoimmunity, vol. 36, no. 8, pp. 511–518, 2003. View at Publisher · View at Google Scholar · View at Scopus
46. M. Hashizume and M. Mihara, “The roles of interleukin-6 in the pathogenesis of rheumatoid arthritis,” Arthritis, vol. 2011, Article ID 765624, 8 pages, 2011. View at Publisher · View at Google Scholar
47. T. Alonzi, E. Fattori, D. Lazzaro et al., “Interleukin 6 is required for the development of collagen-induced arthritis,” Journal of Experimental Medicine, vol. 187, no. 4, pp. 461–468, 1998. View at Publisher · View at Google Scholar · View at Scopus
48. T. Kagari, H. Doi, and T. Shimozato, “The importance of IL-1β and TNF-α, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis,” Journal of Immunology, vol. 169, no. 3, pp. 1459–1466, 2002. View at Scopus
49. A. Ogata, T. Hirano, Y. Hishitani, and T. Tanaka, “Safety and efficacy of tocilizumab for the treatment of rheumatoid arthritis,” Clinical Medicine Insights, vol. 5, pp. 27–42, 2012.
50. R. Horai, S. Saijo, H. Tanioka et al., “Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice,” Journal of Experimental Medicine, vol. 191, no. 2, pp. 313–320, 2000. View at Publisher · View at Google Scholar · View at Scopus
51. A. Nakajima, T. Matsuki, M. Komine et al., “TNF, but not IL-6 and IL-17, is crucial for the development of T cell-independent psoriasis-like dermatitis in Il1rn^−/− mice,” Journal of Immunology, vol. 185, no. 3, pp. 1887–1893, 2010. View at Publisher · View at Google Scholar · View at Scopus
52. D. McGonagle, “Enthesitis: an autoinflammatory lesion linking nail and joint involvement in psoriatic disease,” Journal of the European Academy of Dermatology and Venereology, vol. 23, no. 1, pp. 9–13, 2009. View at Publisher · View at Google Scholar · View at Scopus