Macrophage Migration Inhibitory Factor: A Multifunctional Cytokine in Rheumatic Diseases

Figure 1

The orchestration of complicated cytokine networks by MIF in inflammatory/immune responses. MIF is a multipotent cytokine involved in the regulation of immune and inflammatory responses via other various mediators, and plays a key role in regulating a number of inflammatory and immune-mediated diseases seen in pannus, blood vessels, kidney, gut, and brain.