Table 1: Biological activities of MIF.

Chemotactic activities
 Monocytesstimulation/inhibition: dependent on its concentration
 T lymphocytes
 ECs
 Vascular smooth muscle cells
 Fibroblasts
Angiogenic activities
Antiapoptotic activities
Stimulation of cell proliferation
Induction of mediators
 CytokinesTNF-
IL-1, 6, 8, 12
CCL2
 Growth factorVEGF
 Adhesion molecules
ICAM-1
VCAM-1
E-selectin
P-selectin
 ProteinasesMMP-1, 3, 9, 13
 Nitric oxide
 Superoxide

Chemotactic activities of MIF against monocytes/macrophages may be dependent on its concentration. VEGF; vascular endothelial growth factor, ICAM-1; intercellular cell adhesion molecule-1, VCAM-1; vascular cell adhesion molecule-1, MMP; matrix metalloproteinase.