Review Article
Rationale for Targeting CD6 as a Treatment for Autoimmune Diseases
Table 2
Anti-CD6 SRCR-D1 mAbs and functional effects.
| Clone | Functional response | Cross-link | Author |
| BLTP6a, UMCD6 and MT502 | Block T-cell Ag dependant activation | No | [18] | 161.8 | Induces Erk1/2 activation | Yes | [37] | IorT1, 2H1, T12, 6D3, Dako-CD6 | Enhance anti-CD3, anti-CD28 and PMA T cell proliferation | Yes | [70, 71] | Ior T1 | Protects B-CLL from anti-IgM apoptosis | Yes | [25] | UMCD6 | Blocks T-cell/keratinocyte interaction | No | [18] |
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