Table 2: Anti-CD6 SRCR-D1 mAbs and functional effects.

CloneFunctional responseCross-linkAuthor

BLTP6a, UMCD6 and MT502Block T-cell Ag dependant activationNo[18]
161.8Induces Erk1/2 activationYes[37]
IorT1, 2H1, T12, 6D3, Dako-CD6Enhance anti-CD3, anti-CD28 and PMA T cell proliferationYes[70, 71]
Ior T1Protects B-CLL from anti-IgM apoptosisYes[25]
UMCD6Blocks T-cell/keratinocyte interactionNo[18]