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Arthritis
Volume 2010 (2010), Article ID 759868, 6 pages
http://dx.doi.org/10.1155/2010/759868
Review Article

B-Cell Pathology in Juvenile Idiopathic Arthritis

1Pediatric Hematology, Oncology and Neurooncology, Pediatric Stem Cell Transplantation Program, Children's Hospital, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany
2Pediatric Rheumatology, Immunology and Infectious Diseases, Children's Hospital, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany
3Vivantes Children's Hospital, Friedrichshain, Landsberger Allee 49, 10249 Berlin, Germany

Received 29 September 2010; Accepted 4 November 2010

Academic Editor: Ruben Burgos-Vargas

Copyright © 2010 V. Wiegering et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Juvenile Idiopathic Arthritis (JIA) is the most common cause of chronic arthritis in childhood and adolescents and encompasses a heterogeneous group of different diseases. Due to the promising results of B-cell depleting therapies in rheumatoid arthritis the role of B-cells in autoimmune diseases has to be discussed in a new context. Additionally, experiments in mouse models have shed new light on the antibody-independent role of B-cells in the development of autoimmune diseases. In this review we will discuss the importance of B-cells in the pathogenesis of JIA appraising the question for an immunological basis of B-cell targeted therapy in JIA.