203901.fig.001
Figure 1: Schematic representation of the complex network that links white adipose tissue dysfunction, bone, and cartilage tissues. Dysfunctional fat produces an excess of proinflammatory adipokines that are able to interact with bone cells, synovial cells, and chondrocytes by inducing proinflammatory mediators (cytokines, ROS, NO) and cartilage degradative factors (metalloproteases and ADAMTSs).