Quantitative Cartilage Imaging in Knee Osteoarthritis

Table 2

Rate of change and sensitivity to change over 2 years in 28 participants with Kellgren-Lawrence grade [KLG] 3, and test-retest reproducibility in 33 participants with KLG0 to KLG3 for various cartilage morphology metrics and regions of interest in the medial femorotibial compartment.

	MT				cMF 60%
	MC%	SRM	P	RMSCV%	MC%	SRM	P	RMSCV%
VC	−2.3	−0.44	.03	2.5%	−3.5	−0.32	.10	2.6%
tAB	0.5	0.37	.06	1.0%	−0.1	−0.04	.84	1.1%
AC	−0.9	−0.33	.09	1.0%	−1.7	−0.22	.26	1.3%
cAB	−1.0	−0.29	.14	1.0%	−3.0	−0.36	.07	1.1%
VCtAB	−2.7	−0.59	.00	1.9%	−4.0	−0.33	.09	2.0%
ThCtAB.aMe	−2.6	−0.58	.01	1.9%	−3.6	−0.31	.12	1.7%
ThCtAB.bMe	−2.8	−0.62	.00	1.9%	−3.3	−0.29	.13	1.9%
ThCtAB.cMe	−2.5	−0.56	.01	2.0%	−3.9	−0.33	.10	1.7%
ThCcAB.aMe	−1.4	−0.43	.03	1.9%	−1.5	−0.18	.34	1.7%
ThCcAB.bMe	−1.5	−0.48	.02	1.9%	−1.2	−0.15	.43	1.9%
ThCcAB.cMe	−1.3	−0.42	.04	2.0%	−2.0	−0.23	.23	1.7%
ThCtAB.aMax	−1.4	−0.27	.17	4.4%	0.0	0.00	.99	2.8%
ThCtAB.bMax	−1.7	−0.30	.12	4.2%	0.7	0.10	.61	3.3%
ThCtAB.cMax	−1.1	−0.18	.35	5.3%	−0.5	−0.09	.65	3.2%
ThCtAB.aMav	−1.4	−0.31	.11	3.8%	−0.3	−0.05	.79	2.5%
ThCtAB.bMav	−1.7	−0.35	.07	3.5%	0.0	0.00	.98	2.8%
ThCtAB.cMav	−1.3	−0.25	.19	4.5%	−0.5	−0.09	.65	2.8%

MC%: mean change in %, SRM: standardized response mean (= mean change/SD of change), P: level of significance of change using a paired 𝑡-test without adjustment for multiple comparisons; RMSCV%: root mean square coefficient of variation of test-retest acquisitions at baseline, with repositioning in between scans. For other abbreviations, please see Table 1. Note that values are given for the “long” femoral region of interest, that is, a 60% distance between the trochlear notch and the posterior end of both femoral condyles.