Table 2: Rate of change and sensitivity to change over 2 years in 28 participants with Kellgren-Lawrence grade [KLG] 3, and test-retest reproducibility in 33 participants with KLG0 to KLG3 for various cartilage morphology metrics and regions of interest in the medial femorotibial compartment.

MTcMF 60%
MC%SRMPRMSCV%MC%SRMPRMSCV%

VC−2.3−0.44.032.5%−3.5−0.32.102.6%
tAB0.50.37.061.0%−0.1−0.04.841.1%
AC−0.9−0.33.091.0%−1.7−0.22.261.3%
cAB−1.0−0.29.141.0%−3.0−0.36.071.1%
VCtAB−2.7−0.59.001.9%−4.0−0.33.092.0%
ThCtAB.aMe−2.6−0.58.011.9%−3.6−0.31.121.7%
ThCtAB.bMe−2.8−0.62.001.9%−3.3−0.29.131.9%
ThCtAB.cMe−2.5−0.56.012.0%−3.9−0.33.101.7%
ThCcAB.aMe−1.4−0.43.031.9%−1.5−0.18.341.7%
ThCcAB.bMe−1.5−0.48.021.9%−1.2−0.15.431.9%
ThCcAB.cMe−1.3−0.42.042.0%−2.0−0.23.231.7%
ThCtAB.aMax−1.4−0.27.174.4%0.00.00.992.8%
ThCtAB.bMax−1.7−0.30.124.2%0.70.10.613.3%
ThCtAB.cMax−1.1−0.18.355.3%−0.5−0.09.653.2%
ThCtAB.aMav−1.4−0.31.113.8%−0.3−0.05.792.5%
ThCtAB.bMav−1.7−0.35.073.5%0.00.00.982.8%
ThCtAB.cMav−1.3−0.25.194.5%−0.5−0.09.652.8%

MC%: mean change in %, SRM: standardized response mean (= mean change/SD of change), P: level of significance of change using a paired 𝑡 -test without adjustment for multiple comparisons; RMSCV%: root mean square coefficient of variation of test-retest acquisitions at baseline, with repositioning in between scans. For other abbreviations, please see Table 1. Note that values are given for the “long” femoral region of interest, that is, a 60% distance between the trochlear notch and the posterior end of both femoral condyles.