Serum Leptin Concentration Positively Correlates with Body Weight and Total Fat Mass in Postmenopausal Japanese Women with Osteoarthritis of the Knee

Table 1

Characteristics of study subjects.

	Mean ± SD	Range
Age (years)	66.4±8.2	50–88
Height (m)	1.56±0.05	1.47–1.65
Body weight (kg)	58.4±8.2	44–80
Body mass index (kg/m^2)	24.1±3.4	16.9–33.3
Lumbar spine BMD (g/cm^2)	0.864±0.204	0.524–1.316
Whole body BMD (g/cm^2)	0.866±0.108	0.647–1.109
Lean body mass (g)	34229±7548	20720–64203
Total fat mass (g)	24734±6135	14302–41201
Total fat percent (%)	40.8±5.3	29.7–51.5
Serum BAP (U/L)	28.1±9.8	11.7–49.8
Serum OC (ng/mL)	5.7±2.2	1.7–11.9
Urinary pyridinoline (pmol/μmol Cr)	32.5±9.3	19.3–63.6
Urinary deoxypyridinoline (nmol/mmol Cr)	6.5±2.0	2.8–10.1
Urinary NTX (nmol BCE/mmol Cr)	57.9±21.4	8.2–95.7
Serum leptin (ng/mL)	9.7±4.7	1.8–21.1
Radiographic grade	2.47±1.00	1–4

BMD: bone mineral density, BAP: bone-specific alkaline phosphatase, OC: osteocalcin, NTX: cross-linked N-terminal telopeptides of type I collagen, BCE: bone collagen equivalent, Cr: creatinine.
Normal ranges of urinary pyridinoline, deoxypyridinoline, and NTX were 17.7–41.9 pmol/μmol Cr and 2.8–7.6 nmol/mmol Cr, and 9.3–54.3 nM BCE/mM Cr, respectively. Normal ranges of serum BAP, OC, and leptin were 7.9–20.9 U/L, 3.1–12.7 ng/mL, and 2.5–21.8 ng/mL, respectively.