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Arthritis
Volume 2011 (2011), Article ID 683970, 16 pages
http://dx.doi.org/10.1155/2011/683970
Review Article

Developmental Mechanisms in Articular Cartilage Degradation in Osteoarthritis

Institute of Rheumatology, Russian Academy of Medical Sciences, Kashirskoye Shosse 34A, Moscow 115522, Russia

Received 5 August 2010; Accepted 9 December 2010

Academic Editor: Henning Bliddal

Copyright © 2011 Elena V. Tchetina. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Osteoarthritis is the most common arthritic condition, which involves progressive degeneration of articular cartilage. The most recent accomplishments have significantly advanced our understanding on the mechanisms of the disease development and progression. The most intriguing is the growing evidence indicating that extracellular matrix destruction in osteoarthritic articular cartilage resembles that in the hypertrophic zone of fetal growth plate during endochondral ossification. This suggests common regulatory mechanisms of matrix degradation in OA and in the development and can provide new approaches for the treatment of the disease by targeting reparation of chondrocyte phenotype.