About this Journal Submit a Manuscript Table of Contents
Volume 2011 (2011), Article ID 741071, 7 pages
Research Article

Rheumatoid Factor and Its Interference with Cytokine Measurements: Problems and Solutions

1The Parker Institute, Frederiksberg Hospital, 2000 Frederiksberg, Denmark
2Faculty of Health Science, University of Copenhagen, 2200 Copenhagen N, Denmark
3Centre for Sensory-Motor Interaction, Aalborg University, 9220 Aalborg, Denmark

Received 4 November 2010; Revised 1 April 2011; Accepted 27 April 2011

Academic Editor: Shigeru Kotake

Copyright © 2011 Else Marie Bartels et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [12 citations]

The following is the list of published articles that have cited the current article.

  • Donald F. LeGatt, George B. Blakney, Trefor N. Higgins, Kareena L. Schnabl, Carol E. Shalapay, Valerian C. Dias, and James C. Wesenberg, “The Effect of Paraproteins and Rheumatoid Factor on Four Commercial Immunoassays for Vancomycin,” Therapeutic Drug Monitoring, vol. 34, no. 3, pp. 306–311, 2012. View at Publisher · View at Google Scholar
  • Ulrike Hampel, Stefan Sesselmann, Pavel Iserovich, Saadettin Sel, Friedrich Paulsen, and Robert Sack, “Chemokine and cytokine levels in osteoarthritis and rheumatoid arthritis synovial fluid,” Journal of Immunological Methods, 2013. View at Publisher · View at Google Scholar
  • Joanne Goodman, and Balaji Agoram, “Analytical assay platforms for soluble target engagement biomarkers: old favorites and emerging technologies,” Bioanalysis, vol. 5, no. 23, pp. 2919–2931, 2013. View at Publisher · View at Google Scholar
  • Else Marie Bartels, and Søren Ribel-Madsen, “Cytokine measurements and possible interference from heterophilic antibodies – Problems and solutions experienced with rheumatoid factor,” Methods, 2013. View at Publisher · View at Google Scholar
  • Francesca Ingegnoli, Roberto Castelli, and Roberta Gualtierotti, “Rheumatoid Factors: Clinical Applications,” Disease Markers, vol. 35, pp. 727–734, 2013. View at Publisher · View at Google Scholar
  • Tue W Kragstrup, Thomas Vorup-Jensen, Bent Deleuran, and Malene Hvid, “A simple set of validation steps identifies and removes false results in a sandwich enzyme-linked immunosorbent assay caused by anti-animal IgG antibodies in plasma from arthritis patients,” SpringerPlus, vol. 2, no. 1, pp. 263, 2013. View at Publisher · View at Google Scholar
  • Boris Gorovits, Jim McNally, Corinna Fiorotti, and Sheldon Leung, “Protein-based matrix interferences in ligand-binding assays,” Bioanalysis, vol. 6, no. 8, pp. 1131–1140, 2014. View at Publisher · View at Google Scholar
  • Bettina E. Holm, Noreen Sandhu, Julie Tronstrøm, Magnus Lydolph, Nicole H. Trier, and Gunnar Houen, “Species cross-reactivity of rheumatoid factors and implications for immunoassays,” Scandinavian Journal of Clinical & Laboratory Investigation, pp. 1–13, 2014. View at Publisher · View at Google Scholar
  • Ozlem Gulbahar, Ceyla Konca Degertekin, Mujde Akturk, Mehmet Muhittin Yalcin, Isilay Kalan, Gokce Filiz Atikeler, Alev Eroglu Altinova, Ilhan Yetkin, Metin Arslan, and Fusun Toruner, “A Case With Immunoassay Interferences in the Measurement of Multiple Hormones,” Journal Of Clinical Endocrinology & Metabolism, vol. 100, no. 6, pp. 2147–2153, 2015. View at Publisher · View at Google Scholar
  • Paulina Chalan, Johan Bijzet, Anke van den Berg, Joost Kluiver, Bart-Jan Kroesen, Annemieke M. H. Boots, and Elisabeth Brouwer, “Analysis of serum immune markers in seropositive and seronegative rheumatoid arthritis and in high-risk seropositive arthralgia patients,” Scientific Reports, vol. 6, pp. 26021, 2016. View at Publisher · View at Google Scholar
  • Shiva Mongolu, Annie E. Armston, Erin Mozley, and Azraai Nasruddin, “Heterophilic antibody interference affecting multiple hormone assays: Is it due to rheumatoid factor?,” Scandinavian Journal of Clinical and Laboratory Investigation, pp. 1–3, 2016. View at Publisher · View at Google Scholar
  • Guozhen Liu, Meng Qi, Mark R. Hutchinson, Guangfu Yang, and Ewa M. Goldys, “Recent advances in cytokine detection by immunosensing,” Biosensors and Bioelectronics, 2016. View at Publisher · View at Google Scholar